UVRAG,肿瘤抑制基因UVRAG抗体

产品编号HZ-9923R
英文名称UVRAG
中文名称肿瘤抑制基因UVRAG抗体
别 名DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 免疫学 信号转导 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse,
UVRAG,肿瘤抑制基因UVRAG抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Human UVRAG/DHTX
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
UVRAG,肿瘤抑制基因UVRAG抗体PubMedPubMed
产品介绍background:
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

Subunit:
Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1.

Subcellular Location:
Late endosome. Lysosome. Early endosome. Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.

UVRAG,肿瘤抑制基因UVRAG抗体Tissue Specificity:
Highly expressed in brain, lung, kidney and liver.

DISEASE:
Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).

Similarity:
Contains 1 C2 domain.

Database links:
Entrez Gene: 7405 Human
Entrez Gene: 78610 Mouse
Omim: 602493 Human
SwissProt: Q9P2Y5 Human
Unigene: 728868 Human
Unigene: 323072 Mous

UVRAG,肿瘤抑制基因UVRAG抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

UVRAG肿瘤抑制基因可对自体吞噬起到调控机制，以完成自我运输调节机制。此外，UVRAG肿瘤抑制因子还是包膜上物质转运通路上的重要效应蛋白，它可调控细胞的内吞和自体吞噬作用。