性能参数
产品名称： 小鼠抗细胞色素P450 1A1单克隆抗体
英文名称： CYP1A1
抗体货号： hzm-51210M
产品规格： 50ul/100ul
级 别： , 分析纯,
产品产地： 中国/上海
品牌商标： HZbscience
价 格： 860-1580元
抗原： IgG
抗原来源： Mouse
抗体来源： Mouse
适用物种： 见说明书
应用范围： WB=1:500-2000 ELISA=1:500-1000
更新时间： 2020/11/21 10:31:00
详细资料：
实验方法技术资料
浏览人数：387
供应商： 上海沪震实业有限公司
诚信指数：13682点
了解更多：进入公司展台
使用范围：仅限科研使用，不能应用于临床
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生物在线声明：以上所展示的信息由企业自行提供，内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。
产品详细描述
Mouse Anti-CYP1A1 antibody
| 产品编号 | hzm-51210M |
| 英文名称 | CYP1A1 |
| 中文名称 | 小鼠抗细胞色素P450 1A1单克隆抗体 |
| 别 名 | Cytochrome p450 1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CYP 1; CYP1A1; CYPIA1; Cytochrome P1-450; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P1 450; P450 C; P450 form 6; P450 P1; Xenobiotic monooxygenase. |
| 研究领域 | 细胞生物 免疫学 合成与降解 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | 10G3 |
| 交叉反应 | Human, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYP1A1: |
| 亚 型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several cofactors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Subcellular Location: Cytochrome P450 1A1: Cytoplasm. Cytochrome P450MT2A: Endoplasmic reticulum membrane. Mitochondrion membrane. Microsome membrane. Cytochrome P450MT2B: Endoplasmic reticulum. Mitochondrion. Tissue Specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. Similarity: Belongs to the cytochrome P450 family. SWISS: A9YTQ3 Gene ID: 57491 Database links: Entrez Gene: 57491 Human Entrez Gene: 11624 Mouse Entrez Gene: 498999 Rat Omim: 606517 Human SwissProt: A9YTQ3 Human SwissProt: Q3U1U7 Mouse SwissProt: Q75NT5 Rat Unigene: 50823 Human Unigene: 290446 Mouse Unigene: 145524 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
生物在线声明：以上所展示的信息由企业自行提供，内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。
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