磷酸化系统性红斑狼疮相关蛋白TREX1抗体-抗体-抗体-生物在线
磷酸化系统性红斑狼疮相关蛋白TREX1抗体

磷酸化系统性红斑狼疮相关蛋白TREX1抗体

商家询价

产品名称: 磷酸化系统性红斑狼疮相关蛋白TREX1抗体

英文名称: Phospho-ATRIP (Ser224)

产品编号: hz-11225R

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-Phospho-ATRIP (Ser224) antibody 

 

产品编号 hz-11225R
英文名称 Phospho-ATRIP (Ser224)
中文名称 磷酸化系统性红斑狼疮相关蛋白TREX1抗体
别    名 ATRIP(Ser224); Phospho-ATRIP(Ser224); P-ATRIP (phospho-Ser224); Phospho-ATRIP (Ser224); AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; Deoxyribonuclease III dnaQ/mutD (E. coli) like; DKFZp434J0310; DKFZp762J2115; DNase III; DRN 3; DRN3; FLJ12343; MGC20625; MGC26740; Three prime repair exonuclease 1; TREX 1; TREX1; TREX1 protein; MGC21482; 3' repair exonuclease 1; 3'-5' exonuclease TREX1.  
   
产品类型 磷酸化抗体 
研究领域 细胞生物  免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human ATRIP around the phosphorylation site of Ser224 [HV(p-S)PR]:HV(p-S)PR 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.

Function:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

Subunit:
Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.

Subcellular Location:
Nucleus. Redistributes to discrete nuclear foci upon DNA damage. 

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by ATR. 

Similarity:
Belongs to the ATRIP family.

SWISS:
Q8WXE1

Gene ID:
84126

Database links:

Entrez Gene: 84126 Human

Entrez Gene: 235610 Mouse

Entrez Gene: 301014 Rat

Omim: 606605 Human

SwissProt: Q8WXE1 Human

SwissProt: Q8BMG1 Mouse

Unigene: 694840 Human

Unigene: 100622 Mouse

 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications