磷酸化泛素交联酶抗体
产品名称: 磷酸化泛素交联酶抗体
英文名称: Phosphor-UBE2s(Thr152)
产品编号: hz-10737R
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-Phosphor-UBE2s(Thr152) antibody
产品编号 | hz-10737R |
英文名称 | Phosphor-UBE2s(Thr152) |
中文名称 | 磷酸化泛素交联酶抗体 |
别 名 | UBE2s(Phosphor T152); Phosphor-UBE2s(T152); E2 EPF; E2EPF; EPF5; UBE2S; Ubiquitin carrier protein S; Ubiquitin conjugating enzyme E2 24 kD; Ubiquitin conjugating enzyme E2S; Ubiquitin protein ligase S; AA409170; MGC101982; UBE2S_HUMAN. |
产品类型 | 磷酸化抗体 |
研究领域 | 免疫学 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 24kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human UBE2s around the phosphorylation site of Thr152:LL(p-T)EI |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008] Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Subunit: Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL. Post-translational modifications: Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome. Similarity: Belongs to the ubiquitin-conjugating enzyme family. Gene ID: 27338 Database links: Entrez Gene: 617703 Cow Entrez Gene: 27338 Human Entrez Gene: 77891 Mouse Entrez Gene: 292588 Rat GenBank: NP_055316.2 Human Omim: 610309 Human SwissProt: Q1RML1 Cow SwissProt: Q16763 Human SwissProt: Q921J4 Mouse SwissProt: B5DFI8 Rat Unigene: 396393 Human Unigene: 389787 Mouse Unigene: 120398 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |