磷酸化染色质相关蛋白1-γ抗体
产品名称： 磷酸化染色质相关蛋白1-γ抗体
英文名称： phospho-HP1 gamma (Ser83)
产品编号： hz-17374R
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-phospho-HP1 gamma (Ser83) antibody
| 产品编号 | hz-17374R |
| 英文名称 | phospho-HP1 gamma (Ser83) |
| 中文名称 | 磷酸化染色质相关蛋白1-γ抗体 |
| 别 名 | HP1 gamma (phospho S83); p-HP1 gamma (phospho S83); CBX 3; CBX3; CBX3_HUMAN; Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3; Chromobox protein homolog 3; GAMMA; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; Heterochromatin protein HP1 gamma; HP1 gamma; HP1 gamma homolog; HP1 gamma homolog; HP1Hs gamma; HP1Hs gamma; Modifier 2 protein; Modifier 2 protein; S83. HP-1-γ; HP 1γ; HP-1γ; HP-1 γ; HP1γ; HP1 γ; |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rhesus monkey |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human HP1 gamma around the phosphorylation site of Ser83: |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Subcellular Location: Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis. Post-translational modifications: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. Similarity: Contains 2 chromo domains. Gene ID: 11335 Database links: Entrez Gene: 539788 Cow Entrez Gene: 11335 Human Entrez Gene: 12417 Mouse Entrez Gene: 706978 Rhesus monkey Omim: 604477 Human SwissProt: Q13185 Human SwissProt: P23198 Mouse SwissProt: Q5R6X7 Orangutan Unigene: 381189 Human Unigene: 280968 Mouse Unigene: 458234 Mouse Unigene: 485141 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |