FITC标记的细胞周期蛋白依赖性激酶5激活因子1抗体
产品名称： FITC标记的细胞周期蛋白依赖性激酶5激活因子1抗体
英文名称： Anti-CDK5R1/p35/FITC
产品编号： HZ-11611R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-CDK5R1/p35/FITC Conjugated antibody
FITC标记的细胞周期蛋白依赖性激酶5激活因子1抗体
| 产品编号 | bs-11611R-FITC |
| 英文名称 | Anti-CDK5R1/p35/FITC |
| 中文名称 | FITC标记的细胞周期蛋白依赖性激酶5激活因子1抗体 |
| 别 名 | CD5R1_HUMAN; CDK 5R1; CDK5 activator 1; CDK5P35; CDK5R; CDK5R1; Cyclin dependent kinase 5 activator 1; Cyclin dependent kinase 5 regulatory subunit 1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; MGC33831; NCK 5A; NCK5A; Neuronal CDK5 activator; p23; p25; p25 included; p35; p35nck5a; Regulatory partner for CDK5 kinase; Tau protein kinase II 23 kDa subunit; Tau protein kinase II 23kDa subunit; TPKII regulatory subunit. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞周期蛋白 转录调节因子 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human p35 (219-307aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008] Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Activator of TPKII. Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts with RASGRF2. [INTERACTION] Q6ZMQ8-1:AATK; NbExp=2; IntAct=EBI-746189, EBI-2008436; Q6ZMQ8-2:AATK; NbExp=6; IntAct=EBI-746189, EBI-2008441; Q00535:CDK5; NbExp=5; IntAct=EBI-746189, EBI-1041567. [SUBCELLULAR LOCATION] Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. Subcellular Location: Cell membrane. In the primary cortical neurons, p35 is present in the peripheries and nerve terminals and Nucleus. Cytoplasm > perinuclear region. The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. Tissue Specificity: Brain and neuron specific. Post-translational modifications: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo. Probably myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of p35. Similarity: Belongs to the cyclin-dependent kinase 5 activator family. Database links: Entrez Gene: 8851 Human Entrez Gene: 12569 Mouse Entrez Gene: 116671 Rat Omim: 603460 Human SwissProt: Q28199 Cow SwissProt: Q15078 Human SwissProt: P61809 Mouse SwissProt: A7LNG6 Pig SwissProt: P61810 Rat Unigene: 500015 Human Unigene: 142275 Mouse Unigene: 474282 Mouse Unigene: 11213 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白（p35）是细胞周期蛋白依赖性激酶5（CDK5）的神经元特异性激活剂，CDK5的激活是中枢神经系统正常发育所必需的。该蛋白的p35形式由钙蛋白酶裂解，产生P25形式。p35裂解进入p25导致蛋白质从细胞外周向细胞核和核周区的重新定位。P25通过延长CDK5的活性和改变其细胞位置来调节CDK5活性。P25在阿尔茨海默病患者的脑神经元中积累。这种积累与CDK5激酶活性的增加相关，并可能导致微管相关蛋白tau的异常磷酸化形式，这有助于阿尔茨海默病。