FITC标记的Rho GTP酶激活蛋白13抗体
产品名称： FITC标记的Rho GTP酶激活蛋白13抗体
英文名称： Anti-SRGAP1/FITC
产品编号： HZ-11601R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-SRGAP1/FITC Conjugated antibody
FITC标记的Rho GTP酶激活蛋白13抗体
| 产品编号 | bs-11601R-FITC |
| 英文名称 | Anti-SRGAP1/FITC |
| 中文名称 | FITC标记的Rho GTP酶激活蛋白13抗体 |
| 别 名 | ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 124kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SRGAP1 (51-150aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization. Function: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Subunit: Homodimer (Probable). Forms heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG. Tissue Specificity: Expressed in brain, lung, kidney, and testis. Similarity: Contains 1 FCH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain. Database links: Entrez Gene: 57522 Human Entrez Gene: 117600 Mouse Entrez Gene: 314903 Rat Omim: 606523 Human SwissProt: Q7Z6B7 Human SwissProt: Q91Z69 Mouse Unigene: 210751 Human Unigene: 593803 Human Unigene: 288698 Mouse Unigene: 208903 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
SrGAP包含一个高度保守的一级结构，在促进细胞迁移和轴突导向的狭缝ROBO信号中起重要作用。SRGAP1（Sur-Rabo Rho GTP酶激活蛋白1），又名ARHGAP13（Rho GTP酶激活蛋白13），在肾脏、睾丸、肺和脑中起到CDC42和Rho A.的GTP酶激活蛋白的作用，SRGAP1包含FCH（FEs/CIP4同源）结构域、Rho GAP结构域和SH3 DO。主要的。在缝隙的存在下，SRGAP1（通过其SH3结构域）结合到具有较高亲和力的ROBO（负责介导排斥效应的蛋白质）中的cc3基序，并以Rabo/SrGAP依赖性方式抑制CDC42活性。更具体地，SRGAP1增加CDC42的内在GTPASE活性，从而将其转化为其不活跃的、与GDP相关的形式。CDC42的失活最终导致肌动蛋白聚合的减少。