FITC标记的NOMO蛋白抗体-抗体-抗体-生物在线
FITC标记的NOMO蛋白抗体

FITC标记的NOMO蛋白抗体

商家询价

产品名称: FITC标记的NOMO蛋白抗体

英文名称: Anti-NOMO1/FITC

产品编号: HZ-11595R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-NOMO1/FITC Conjugated antibody

FITC标记的NOMO蛋白抗体

 

产品编号 bs-11595R-FITC
英文名称 Anti-NOMO1/FITC
中文名称 FITC标记的NOMO蛋白抗体
别    名 Nodal modulator 1; NOMO 1; Nomo; NOMO1; NOMO1_HUMAN; PM5; pM5 protein; pM5 protein telomeric copy; NOMO1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  信号转导  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 131kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NOMO1 (701-800aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Three highly similar proteins termed NOMO1, NOMO2 and NOMO3, are encoded by a gene mapping to a region of duplication on the p arm of human chromosome 16. All three NOMO proteins share similar functions and have been difficult to characterize individually. NOMO1 (Nodal modulator 1), also known as PM5, is a 1,222 amino acid highly conserved single-pass type I membrane protein expressed in colon tumor tissue and normal colonic mucosa. NOMO proteins are novel antagonists of Nodal signaling which interact with Nicalin to form a Nicalin-NOMO complex, and are rapidly degraded or stabilized by Nicalin. NOMO proteins were once considered candidates for the development of pseudoxanthoma elasticum (PXE), a heritable disorder of connective tissue, as the NOMO genes are located in close proximity to the gene responsible for PXE development (MRP6). 

Function:
May antagonize Nodal signaling.

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Expressed in colon tumor tissue and in adjacent normal colonic mucosa.

Database links:
UniProtKB/Swiss-Prot: Q15155.5

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

三个高度相似的蛋白质被称为NOMO 1、NOMO2和NOMO3,通过基因映射编码到人类染色体16的P臂上的重复区域。所有三个NOMO蛋白具有相似的功能,并且难以单独表征。NOMO1(节调节剂1),又称PM5,是结肠肿瘤组织和正常结肠粘膜中表达的1222氨基酸高度保守的单程I型膜蛋白。NOMO蛋白是Nealin信号的新拮抗剂,与尼卡林相互作用,形成尼卡林-诺莫复合物,并被尼卡林迅速降解或稳定。NOMO蛋白曾经被认为是发展为假结缔组织瘤(PXE)的候选,是一种遗传性结缔组织疾病,因为NOMO基因位于与PXE发育相关的基因(MRP6)的附近。