FITC标记的同源盒蛋白HOXC5抗体
产品名称: FITC标记的同源盒蛋白HOXC5抗体
英文名称: Anti-HOXC5/FITC
产品编号: HZ-11589R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HOXC5/FITC Conjugated antibody
FITC标记的同源盒蛋白HOXC5抗体
产品编号 | bs-11589R-FITC |
英文名称 | Anti-HOXC5/FITC |
中文名称 | FITC标记的同源盒蛋白HOXC5抗体 |
别 名 | CP11; homeo box C5; homeobox C5; Homeobox protein CP11; homeobox protein Hox C5; Homeobox protein Hox-3D; Homeobox protein Hox-C5; Hox 3D; HOX3; HOX3D; HOXC5; HXC5_HUMAN; OTTHUMP00000217386. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 发育生物学 转录调节因子 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 25kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human HOXC5 (151-222aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. HoxC5 is a 222 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Existing as multiple alternatively spliced isoforms, HoxC5 functions as a sequence-specific DNA-binding transcription factor that is part of a regulatory mechanism that provides cells with positional identities during development. The gene encoding HoxC5 maps to a cluster of Hox proteins on chromosome 12 that are essential for morphogenesis. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Subcellular Location: Nucleus. Similarity: Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q00444.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Hox同源框基因编码的蛋白是转录调控因子,在胚胎发育中起着重要作用。HOXC5是一个222个氨基酸的蛋白质,定位于细胞核,并含有一个同源盒DNA结合结构域。HOXC5作为多个交替剪接的异构体存在,作为序列特异性DNA结合转录因子,其是在发育过程中提供具有位置身份的细胞的调节机制的一部分。编码HOXC5的基因编码到12号染色体上的Hox蛋白簇,这是形态发生所必需的。在1亿3200万个碱基中编码超过1100个基因,染色体12构成人类基因组的4.5%。许多骨骼畸形与12号染色体相连,包括软骨发育不良、软骨发育不全和最不典型增生。