FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
产品名称: FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
英文名称: Anti-RAPGEF5/Repac/FITC
产品编号: HZ-11582R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RAPGEF5/Repac/FITC Conjugated antibody
FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
产品编号 | bs-11582R-FITC |
英文名称 | Anti-RAPGEF5/Repac/FITC |
中文名称 | FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体 |
别 名 | GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M Ras regulated Rap GEF; M-Ras-regulated Rap GEF; MR GEF; MR-GEF; MRGEF; Rap guanine nucleotide exchange factor 5; Rapgef5; Related to Epac; Repac; RPGF5_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 神经生物学 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 68kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human RAPGEF5 (151-250aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in brain. Similarity: Contains 1 N-terminal Ras-GEF domain. Contains 1 Ras-GEF domain. Database links: Entrez Gene: 9771 Human Entrez Gene: 217944 Mouse Entrez Gene: 362799 Rat Omim: 609527 Human SwissProt: Q92565 Human SwissProt: Q8C0Q9 Mouse SwissProt: P83900 Rat Unigene: 174768 Human Unigene: 713217 Human Unigene: 227642 Mouse Unigene: 22381 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
成员的Ras(HRAS;国有企业;我190020)函数在信号转导分子GTP酶GTP / GDP的失活,调节开关周期之间的GDP和GTP结合活性的状态。鸟嘌呤核苷酸交换因子(FS),如rapgef5 Ras活化剂,是由收购的刺激GTP GTP结合,以维持的状态和重点之间的联系是细胞表面受体和RAS的激活(rebhun等人,2000年)