FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体-抗体-抗体-生物在线
FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体

FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体

商家询价

产品名称: FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体

英文名称: Anti-RAPGEF5/Repac/FITC

产品编号: HZ-11582R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-RAPGEF5/Repac/FITC Conjugated antibody

FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体

 

产品编号 bs-11582R-FITC
英文名称 Anti-RAPGEF5/Repac/FITC
中文名称 FITC标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
别    名 GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M Ras regulated Rap GEF; M-Ras-regulated Rap GEF; MR GEF; MR-GEF; MRGEF; Rap guanine nucleotide exchange factor 5; Rapgef5; Related to Epac; Repac; RPGF5_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  信号转导  转录调节因子  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAPGEF5 (151-250aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed with highest levels in brain.

Similarity:
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.

Database links:

Entrez Gene: 9771 Human

Entrez Gene: 217944 Mouse

Entrez Gene: 362799 Rat

Omim: 609527 Human

SwissProt: Q92565 Human

SwissProt: Q8C0Q9 Mouse

SwissProt: P83900 Rat

Unigene: 174768 Human

Unigene: 713217 Human

Unigene: 227642 Mouse

Unigene: 22381 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

成员的Ras(HRAS;国有企业;我190020)函数在信号转导分子GTP酶GTP / GDP的失活,调节开关周期之间的GDP和GTP结合活性的状态。鸟嘌呤核苷酸交换因子(FS),如rapgef5 Ras活化剂,是由收购的刺激GTP GTP结合,以维持的状态和重点之间的联系是细胞表面受体和RAS的激活(rebhun等人,2000年)