FITC标记的RNA结合蛋白QK1抗体-抗体-抗体-生物在线
FITC标记的RNA结合蛋白QK1抗体

FITC标记的RNA结合蛋白QK1抗体

商家询价

产品名称： FITC标记的RNA结合蛋白QK1抗体

英文名称： Anti-QK1/FITC

产品编号： HZ-11579R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-QK1/FITC Conjugated antibody

FITC标记的RNA结合蛋白QK1抗体

 

产品编号 bs-11579R-FITC
英文名称 Anti-QK1/FITC
中文名称 FITC标记的RNA结合蛋白QK1抗体
别    名 HKQ; Homolog of mouse quaking QKI KH domain RNA binding protein; Hqk; HQK1; HqkI; Protein quaking; QK; QK1; QK3; QKI; QKI_HUMAN; QKI1; Quaking homolog; Quaking homolog KH domain RNA binding; Quaking homolog KH domain RNA binding mouse; Quaking isoform 1; Quaking protein; RNA binding protein HQK.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human QK1 (121-220aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
QKI is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

Function:
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.

Subunit:
Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.

Post-translational modifications:
Methylated by PRMT1. Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.

Similarity:
Contains 1 KH domain. 

Database links:
UniProtKB/Swiss-Prot: Q96PU8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

QKI是一种341个氨基酸的蛋白质，定位于细胞质和细胞核，并含有一个KH结构域。在脑额叶皮层表达，QKI起到RNA结合蛋白的作用，在髓鞘化中起着重要的作用，并与RNA核心序列5’-NaCuAay-N（1，20）-UAAY-3’特异结合。此外，QKI调节前mRNA剪接和mRNA的输出，并参与保护和促进选择mRNA的稳定性。QKI可以由PRMT1甲基化，并且也可以在其C-末端磷酸化，这是降低QKI mRNA结合亲和力的事件。QKI基因的缺失或缺失与星形细胞肿瘤相关，可能参与了精神分裂症的发病机制。由于选择性剪接事件存在QKI的多个异构体。