FITC标记的造血干细胞特异性相关结合蛋白3抗体
产品名称: FITC标记的造血干细胞特异性相关结合蛋白3抗体
英文名称: Anti-HS1BP3/FITC
产品编号: HZ-11568R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
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Rabbit Anti-HS1BP3/FITC Conjugated antibody
FITC标记的造血干细胞特异性相关结合蛋白3抗体
产品编号 | bs-11568R-FITC |
英文名称 | Anti-HS1BP3/FITC |
中文名称 | FITC标记的造血干细胞特异性相关结合蛋白3抗体 |
别 名 | ETM2; FLJ14249; H1BP3_HUMAN; HCLS1 binding protein 3; HCLS1-binding protein 3; HS1 binding protein 3; HS1 BP3; HS1-BP3; HS1-binding protein 3; Hs1bp3; HSP1BP-3. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 信号转导 干细胞 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 43kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human HS1BP3 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: HS1BP3 is a 392 amino acid protein that contains one PX (phox homology) domain, a leucine zipper, immunoreceptor tyrosine-based inhibitory motif-like motifs and multiple proline-rich regions. Expressed primarily in brain, HS1BP3 is encoded by a gene mapping to human chromosome 2p24.1. The gene encoding HS1BP3 is frequently mutated in familial essential tremor, a disorder characterized by kinetic tremor the the hands, voice or head, though there is no correlation to Parkinson disease. HS1BP3 interacts with HAX-1’s SH3 domain, and may also play a role in the regulation of catecholamine and serotonin metabolism. Acting as a regulator of IL-2 signaling, HS1BP3 is likely involved in lymphocyte activation. Function: May be a modulator of IL-2 signaling. Subunit: Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro Similarity: Contains 1 PX (phox homology) domain. Database links: Entrez Gene: 64342 Human Entrez Gene: 100338217 Rabbit Omim: 609359 Human SwissProt: Q53T59 Human Unigene: 531785 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HS1BP3是含有一个PX(PHOX同源)结构域,392个氨基酸的蛋白质,亮氨酸拉链,基于免疫受体酪氨酸的抑制基序基序和多个富含脯氨酸的区域。主要在脑中表达,HS1BP3由人类染色体2p24.1的基因编码。编码HS1BP3的基因在家族性原发性震颤中经常发生突变,这是一种以运动性震颤、手、声音或头部为特征的疾病,但与帕金森病无相关性。HS1BP3与HAX-1的SH3结构域相互作用,也可能参与儿茶酚胺和5-羟色胺代谢的调节。HS1BP3作为IL-2信号通路的调节因子,可能参与淋巴细胞的活化。