FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)-抗体-抗体-生物在线
FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)

FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)

商家询价

产品名称: FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)

英文名称: Anti-Calcipressin 1/DSCR 1/FITC

产品编号: HZ-11541R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
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  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
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 Rabbit Anti-Calcipressin 1/DSCR 1/FITC Conjugated antibody

FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)

 

产品编号 bs-11541R-FITC
英文名称 Anti-Calcipressin 1/DSCR 1/FITC
中文名称 FITC标记的钙调神经磷酸酶调节蛋白1抗体(唐氏综合征候选区域蛋白1样蛋白1)
别    名 Adapt 78; Adapt78; Calcipressin 1; Calcipressin-1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; DSCR-1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1; RCAN1_HUMAN; RCN 1; RCN1; Regulator of calcineurin 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calcipressin 1 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Subunit:
Interacts with RAF1.

Tissue Specificity:
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Similarity:
Belongs to the RCAN family.

Database links:

Entrez Gene: 1827 Human

Entrez Gene: 54720 Mouse

Entrez Gene: 266766 Rat

Omim: 602917 Human

SwissProt: P53805 Human

SwissProt: Q9JHG6 Mouse

SwissProt: Q6IN33 Rat

Unigene: 282326 Human

Unigene: 265744 Mouse

Unigene: 12942 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

该基因编码的蛋白与钙调神经磷酸酶A相互作用,并抑制钙调神经磷酸酶依赖的信号转导通路,可能影响中枢神经系统的发育。该基因位于唐氏综合征表型的最小候选区域,并且在唐氏综合征胎儿的脑中被过度表达。这种基因的过度表达可能导致神经纤维缠结,例如与阿尔茨海默病相关的神经纤维缠结。三个转录变体编码三个不同的异构体已经发现这个基因。