FITC标记的食欲素前体蛋白OX抗体
产品名称: FITC标记的食欲素前体蛋白OX抗体
英文名称: Anti-Orexin Prepro/FITC
产品编号: HZ-11520R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Orexin Prepro/FITC Conjugated antibody
FITC标记的食欲素前体蛋白OX抗体
产品编号 | bs-11520R-FITC |
英文名称 | Anti-Orexin Prepro/FITC |
中文名称 | FITC标记的食欲素前体蛋白OX抗体 |
别 名 | HCRT; Hypocretin; OX; PPORX; PPOX; Prepro orexin; OREX_HUMAN; Orexin; Hcrt; Hypocretin-1; Hcrt1; Orexin-B; Hypocretin-2; Hcrt2. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 神经生物学 内分泌病 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 3kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Orexin Prepro (70-97aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Prepro-orexin is 130 amino acid long peptide with a putative 33 AA secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors—G-protein coupled receptors (GPCRs) OX1R and OX2R. Orexins (Orexin A and Orexin B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin A and Orexin B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Function: Prepro-orexin is 130 amino acid long peptide with a putative 33 AA secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors—G-protein coupled receptors (GPCRs) OX1R and OX2R. Orexins (Orexin A and Orexin B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin A and Orexin B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Subcellular Location: Cytoplasmic and Endoplasmic reticulum Tissue Specificity: Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Post-translational modifications: Specific enzymatic cleavages at paired basic residues yield the different active peptides. DISEASE: Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Similarity: Belongs to the orexin family. Database links: Entrez Gene: 3060 Human Omim: 602358 Human SwissProt: O43612 Human Unigene: 158348 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PROPRO食欲素是一个130氨基酸长肽,具有33个氨基酸分泌序列,疏水核心,残基,小极性侧链。在大脑中检测到表达,在睾丸中的表达很小。这些神经肽结合并激活两个密切相关的食欲素受体G蛋白偶联受体(GPCRs)OX1R和OX2R。食欲素(Orxin A和Orexin B)是下丘脑选择性表达的一个下丘脑神经肽。食欲素A和Orexin B是通过蛋白水解裂解从同一前体(PRO前食欲素)衍生而来的。