FITC标记的脑多巴胺神经营养因子抗体
产品名称： FITC标记的脑多巴胺神经营养因子抗体
英文名称： Anti-ARMETL1/FITC
产品编号： HZ-11499R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-ARMETL1/FITC Conjugated antibody
FITC标记的脑多巴胺神经营养因子抗体
| 产品编号 | bs-11499R-FITC |
| 英文名称 | Anti-ARMETL1/FITC |
| 中文名称 | FITC标记的脑多巴胺神经营养因子抗体 |
| 别 名 | CDNF; Arginine rich mutated in early stage tumors like 1; ARMET L1; ARMET like protein 1; ARMET-like protein 1; ARMETL 1; Cdnf; CDNF_HUMAN; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARMETL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CDNF is an ARMET family member that is known to be a trophic factor for dopamine neurons. CDNF has been shown to prevent the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF application will restore the dopaminergic function that is reduced by lesions formed from administering 6-OHDA. CDNF further prevents the degeneration of dopaminergic neurons in substantia nigra. CDNF is expressed at high levels in the heart, skeletal muscle, testis and brain. In brain, CDNF has selective expression with the highest being detected in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus. Function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Subcellular Location: Secreted. Tissue Specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. Similarity: Belongs to the ARMET family. Database links: Entrez Gene: 441549 Human Omim: 611233 Human SwissProt: Q49AH0 Human Unigene: 559067 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CDNF是已知为多巴胺神经元营养因子的ARMET家族成员。CDNF已被证明能防止6-羟基多巴胺（6-OHDA）引起的多巴胺能神经元变性。CDNF的应用将恢复多巴胺能的功能，减少由6-OHDA给药所形成的损伤。CDNF进一步防止黑质多巴胺能神经元变性。CDNF在心脏、骨骼肌、睾丸和脑中高表达。在脑中，CDNF具有选择性表达，在小脑浦肯野细胞和脑干区域（包括蓝斑）中被最高检测。