FITC标记的神经丛蛋白B3抗体
产品名称: FITC标记的神经丛蛋白B3抗体
英文名称: Anti-PLXNB3/FITC
产品编号: HZ-11470R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PLXNB3/FITC Conjugated antibody
FITC标记的神经丛蛋白B3抗体
产品编号 | bs-11470R-FITC |
英文名称 | Anti-PLXNB3/FITC |
中文名称 | FITC标记的神经丛蛋白B3抗体 |
别 名 | Plexin B3; KIAA1206; PLEXB3; Plexin-B3; PLEXR; PLXB3_HUMAN; PLXN6; PLXNB3. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 细胞分化 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 202kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Plexin B2 (354-400aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met. Function: Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration. Subunit: Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain). Subcellular Location: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane. Tissue Specificity: Detected at very low levels in several fetal tissues. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. Database links: Entrez Gene: 5365 Human Omim: 300214 Human SwissProt: Q9ULL4 Human Unigene: 632833 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
丛蛋白是脊椎动物中多类信号素的一个大跨膜受体家族。它们被广泛表达,其胞外域的区域都是分散因子受体和信号素域的同源物。丛蛋白可单独作为信号素受体或与神经素结合。丛蛋白被分为四个亚家族,即丛蛋白A、-B、-C和-D。丛蛋白B1和-B2都是SEMA4D的受体,刺激胚胎背根神经节神经元轴突生长。丛蛋白B3结合SAMA5A,它控制轴突导向,并能启动肝细胞生长因子/分散因子受体Met的细胞内信号传导。