FITC标记的鸟嘌呤核苷酸交换因子FARP2抗体
产品名称: FITC标记的鸟嘌呤核苷酸交换因子FARP2抗体
英文名称: Anti-FARP2/FITC
产品编号: HZ-11459R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FARP2/FITC Conjugated antibody
FITC标记的鸟嘌呤核苷酸交换因子FARP2抗体
产品编号 | bs-11459R-FITC |
英文名称 | Anti-FARP2/FITC |
中文名称 | FITC标记的鸟嘌呤核苷酸交换因子FARP2抗体 |
别 名 | FARP 2; FERM; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PLEKHC3; RhoGEF and pleckstrin domain protein 2; FARP2_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 信号转导 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 120kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human FARP2 (601-700aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism. Function: FARP2 is a Rho-guanine nucleotide exchange factor that activates RAC1. It plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Subunit: Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FERM domain. Contains 2 PH domains. Database links: Entrez Gene: 9855 Human Entrez Gene: 227377 Mouse SwissProt: O94887 Human SwissProt: Q91VS8 Mouse Unigene: 726316 Human Unigene: 243091 Mouse Unigene: 28761 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FARP2是一个含有1545个FRM结构域、一个DH结构域和两个pH结构域的蛋白质。它以两种交替剪接的亚型存在,在脑、肺和睾丸以及胚胎海马和皮质神经元中大量表达。FARP2作为Rho鸟嘌呤核苷酸交换因子起着激活RAC1的作用,并被认为调节胚胎神经元轴突重构。SEMA3A结合神经素-1诱导FARP2从丛蛋白A1的解离,从而激活FARP2的RAC GEF活性,这对于排斥生长轴突和抑制神经元粘附是至关重要的。FARP2基因的下调与孤独症有关。