FITC标记的唐氏综合征细胞粘附分子抗体
产品名称： FITC标记的唐氏综合征细胞粘附分子抗体
英文名称： Anti-Dscam/FITC
产品编号： HZ-11456R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Dscam/FITC Conjugated antibody
FITC标记的唐氏综合征细胞粘附分子抗体
| 产品编号 | bs-11456R-FITC |
| 英文名称 | Anti-Dscam/FITC |
| 中文名称 | FITC标记的唐氏综合征细胞粘附分子抗体 |
| 别 名 | CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2, 9; OTTHUMP00000109193 2; SD11109p. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 220kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dscam (301-400aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted. Function: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Subunit: Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts (via extracellular domain) with NTN1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1. Subcellular Location: Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. Tissue Specificity: Primarily expressed in brain. Post-translational modifications: Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin. Similarity: Contains 6 fibronectin type-III domains. Contains 10 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 1826 Human Entrez Gene: 13508 Mouse Entrez Gene: 171119 Rat Omim: 602523 Human SwissProt: O60469 Human SwissProt: Q9ERC8 Mouse SwissProt: Q8VHZ8 Rat Unigene: 397800 Human Unigene: 24399 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DSCAM是属于免疫球蛋白超家族的细胞黏附分子。它主要在脑中表达，包含六个纤连蛋白III型结构域和十个Ig类C2型结构域。在小鼠中，DSCAM负责调节异向性自我回避，姐妹乔木避免交叉的趋势，并在一个区域上按比例扩展。同一性自我回避对于正确的末端分支（树枝化）很重要。在某些细胞类型中，DSCAM也介导异质性的自我回避，这对于细胞体的规则间距和防止超灌注是非常重要的。在人类中，由于选择性剪接而存在两种DSCAM亚型。长的亚型（也称为CHD2-42）是单通道I型膜蛋白，而短的异构体（CHD2-52）缺乏C-末端跨膜包含区（氨基酸1572-2012）。