FITC标记的黑素皮质素4受体抗体
产品名称： FITC标记的黑素皮质素4受体抗体
英文名称： Anti-MC4 Receptor/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MC4 Receptor/FITC Conjugated antibody
FITC标记的黑素皮质素4受体抗体
| 产品编号 | bs-11417R-FITC |
| 英文名称 | Anti-MC4 Receptor/FITC |
| 中文名称 | FITC标记的黑素皮质素4受体抗体 |
| 别 名 | MC4 R; MC4-R; MC4R; MC4R_HUMAN; Melanocortin 4 receptor; Melanocortin receptor 4; MGC126851; MGC138197. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MC4 Receptor (1-50aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The melanocortin family comprises the Alpha-, Beta- and Gamma- melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues. Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase. Subunit: Interacts with ATRNL1. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Brain, placental, and gut tissues. DISEASE: Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 4160 Human Entrez Gene: 17202 Mouse Entrez Gene: 25635 Rat Omim: 155541 Human SwissProt: P32245 Human SwissProt: P56450 Mouse SwissProt: P70596 Rat Unigene: 532833 Human Unigene: 229447 Mouse Unigene: 10620 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
melanocortin家族包括α-、β-和γ-黑素细胞刺激（MSH）和促肾上腺皮质。这些的受体是七个跨膜G蛋白偶联蛋白，激活腺苷酸环化酶。五个黑皮质素受体已被克隆，并表现出不同的亲和力和表达模式。MC1-R（MSH-R）在黑素细胞和肾上腺皮质组织中表达。MC2-R是ACTH受体，主要表达于肾上腺皮质。MC3-R已被发现在脑的特定区域，并在胎盘和肠中也表达。MC4-R主要在脑中表达，而MC5-R在大多数组织中表达水平较低。