FITC标记的原钙粘蛋白γA5抗体-抗体-抗体-生物在线
FITC标记的原钙粘蛋白γA5抗体

FITC标记的原钙粘蛋白γA5抗体

商家询价

产品名称: FITC标记的原钙粘蛋白γA5抗体

英文名称: Anti-PCDHGA5/FITC

产品编号: HZ-11147R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
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  • 所在区域 : 上海
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 Rabbit Anti-PCDHGA5/FITC Conjugated antibody

FITC标记的原钙粘蛋白γA5抗体

 

产品编号 bs-11147R-FITC
英文名称 Anti-PCDHGA5/FITC
中文名称 FITC标记的原钙粘蛋白γA5抗体
别    名 PCDG3_HUMAN; PCDH-gamma-A3; PCDHGA3; protocadherin gamma subfamily A, 3; Protocadherin gamma-A3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  细胞粘附分子  细胞骨架  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCDHGA5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protocadherein gamma cluster consists of three subfamilies (A, B and C). As a member of the gamma subfamily A, PCDHGA5 (Protocadherin gamma A5) is a 931 amino acid protein that is one of 22 proteins encoded by the protocadherin gamma cluster. Typical of gamma protocadherins, PCDHGA5 contains six cadherin motifs and is a type I transmembrane receptor expressed in the central nervous system. With localization to synapses, members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGA5 that are produced as a result of alternative splicing events.

Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein 

Similarity:
Contains 6 cadherin domains.

Database links:
UniProtKB/Swiss-Prot: Q9Y5G8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

原粘蛋白是一大类钙黏蛋白样细胞粘附蛋白,参与脑内神经元连接的建立和维持。共有三个原螯合蛋白基因簇,分别为α、β和γ,它们均含有多个排列整齐的基因。本文中的Gamma簇由三个亚科(A、B和C)组成。作为γ亚家族A的成员,PCDHGA5(原粘蛋白γ-A5)是由原粘蛋白γ簇编码的22种蛋白质之一的931氨基酸蛋白。典型的γ-原粘蛋白,PCDHGA5包含六个钙粘素基序,是I型跨膜受体在中枢神经系统中表达。随着突触的定位,原核粘附分子的Gamma簇成员对神经元存活至关重要。作为替代剪接事件的结果,产生了两种PCDHGA5异构体。