FITC标记的转移生长因子β3（TGFβ3）抗体
产品名称： FITC标记的转移生长因子β3（TGFβ3）抗体
英文名称： Anti-TGF beta 3/FITC
产品编号： HZ-4907R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TGF beta 3/FITC Conjugated antibody
FITC标记的转移生长因子β3（TGFβ3）抗体
| 产品编号 | bs-4907R-FITC |
| 英文名称 | Anti-TGF beta 3/FITC |
| 中文名称 | FITC标记的转移生长因子β3（TGFβ3）抗体 |
| 别 名 | ARVD; TGF beta 3; TGF beta3; TGF-beta-3; TGFB 3; TGFB3; TGFB3_HUMAN; transforming growth factor beta 3; Transforming growth factor beta-3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 干细胞 生长因子和激素 转录调节因子 血管内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, G |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12/47kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TGF beta 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF beta. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF beta 3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF beta 3 overexpresses in extramammary Paget’s disease (EPD) and downregulates in Bowen’s disease, indicating that its expression is a useful indicator of tumor activity. TGF beta 3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF beta 3 circulation appear to be representative of TGF beta 3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGF beta production by modulating mRNA levels and c-Jun activity. Function: Involved in embryogenesis and cell differentiation. Subunit: Homodimer; disulfide-linked. Interacts with ASPN. Subcellular Location: Secreted. DISEASE: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) ; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Similarity: Belongs to the TGF-beta family. Database links: Entrez Gene: 7043 Human Entrez Gene: 21809 Mouse Entrez Gene: 25717 Rat Omim: 190230 Human SwissProt: P10600 Human SwissProt: P17125 Mouse SwissProt: Q07258 Rat Unigene: 592317 Human Unigene: 3992 Mouse Unigene: 7018 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转化生长因子βS（TGF-βS）最初是由于它们在TGF-β存在下促进大鼠NRK成纤维细胞的锚定独立生长的能力而发现的。TGF-β1、TGF-β2和TGF-β3均被合成为非常相似的前体蛋白，其中每一种蛋白被裂解以产生与分子的潜在部分相关联的112氨基酸多肽。TGF-β3介导了许多在胚胎发育、细胞分化和上皮稳态中发生的细胞间相互作用。TGF-β3在乳房外佩吉特病（EPD）中过度表达，并在Bowen病中下调，表明其表达是肿瘤活性的一个有用指标。TGF-β3水平与血清中IGF-1和骨钙素水平密切相关。TGF-β3循环的显著量似乎是骨中TGF-β3表达的代表，并且可能部分来自骨。糖皮质激素可通过调节mRNA水平和c-Jun活性阻断TGF-β产生。