FITC标记的钙激活钾通道蛋白4抗体
产品名称： FITC标记的钙激活钾通道蛋白4抗体
英文名称： Anti-KCNN4/FITC
产品编号： HZ-6675R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-KCNN4/FITC Conjugated antibody
FITC标记的钙激活钾通道蛋白4抗体
| 英文名称 | Anti-KCNN4/FITC |
| 中文名称 | FITC标记的钙激活钾通道蛋白4抗体 |
| 别 名 | hIKCa1; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 通道蛋白 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KCNN4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Subunit: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in non-excitable tissues. Post-translational modifications: Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. Similarity: Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. Database links: Entrez Gene: 3783 Human Entrez Gene: 16534 Mouse Entrez Gene: 65206 Rat Omim: 602754 Human SwissProt: O15554 Human SwissProt: O89109 Mouse SwissProt: Q9QYW1 Rat Unigene: 10082 Human Unigene: 9911 Mouse Unigene: 44212 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
形成由细胞内钙激活的与电压无关的钾通道。激活后膜超极化，促进钙内流。在幼稚T细胞的再活化过程中需要最大的钙内流和增殖。通道被克霉唑和Cabydodo毒素阻断，但对APAMIN不敏感。