FITC标记的Toll样受体7抗体
产品名称: FITC标记的Toll样受体7抗体
英文名称: Anti-TLR7/FITC
产品编号: HZ-6601R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-TLR7/FITC Conjugated antibody
FITC标记的Toll样受体7抗体
英文名称 | Anti-TLR7/FITC |
中文名称 | FITC标记的Toll样受体7抗体 |
别 名 | TLR-7;PRO285; TLR 7; Tlr7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 免疫学 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 121kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human TLR7 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Tissue Specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Similarity: Belongs to the Toll-like receptor family. Contains 27 LRR (leucine-rich) repeats. Contains 1 TIR domain. Database links: Entrez Gene: 493686 Cow Entrez Gene: 51284 Human Entrez Gene: 170743 Mouse Omim: 300365 Human SwissProt: Q9NYK1 Human SwissProt: P58681 Mouse Unigene: 101913 Cow Unigene: 659215 Human Unigene: 23979 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
先天免疫和适应性免疫的关键组成部分。TLRs(Toll样受体)通过识别微生物特异的分子模式来控制宿主对病原体的免疫应答。TLR7是由单链RNA激活的核苷酸检测TLR。通过MyD88和TRAF6作用,导致NF-κB活化、细胞因子分泌和炎症反应。