FITC标记的酪氨酸蛋白激酶A5受体抗体
产品名称: FITC标记的酪氨酸蛋白激酶A5受体抗体
英文名称: Anti-Eph receptor A5/FITC
产品编号: HZ-6599R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
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Rabbit Anti-Eph receptor A5/FITC Conjugated antibody
FITC标记的酪氨酸蛋白激酶A5受体抗体
英文名称 | Anti-Eph receptor A5/FITC |
中文名称 | FITC标记的酪氨酸蛋白激酶A5受体抗体 |
别 名 | bsk; CEK 7; Eck like sequence 1; EHK 1; Els 1; Eph homology kinase 1; EphA5; Ephrin type A receptor 5; HEK 7; Receptor protein tyrosine kinase HEK 7; Rek 7; TYRO 4; Tyrosine protein kinase receptor EHK 1; EPHA5_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 心血管 细胞生物 发育生物学 神经生物学 信号转导 激酶和磷酸酶 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, Guinea Pig, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 114kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human EphA5/Eph receptor A5 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7, is a member of the Eph receptor family, which binds members of the Ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine. Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Tissue Specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD (Eph ligand-binding) domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 2044 Human Entrez Gene: 13839 Mouse Entrez Gene: 79208 Rat Omim: 600004 Human SwissProt: P54755 Chicken SwissProt: P54756 Human SwissProt: Q60629 Mouse SwissProt: P54757 Rat Unigene: 654492 Human Unigene: 137991 Mouse Unigene: 438006 Mouse Unigene: 24569 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
EPHA5,也称为EHK1、BSK、CEK7、HEK7和Rek7,是EFP-受体家族的成员,它与EPHRIN配体家族的成员结合。存在两类受体,A和B,其胞外域由球状结构域、富含半胱氨酸的结构域和两种纤连蛋白III型结构域组成,其次是跨膜区和胞质区。胞质区是具有两个酪氨酸的主要膜区,主要的磷酸化位点,以及激酶结构域,以及C-末端中的保守的无菌α基序(山姆),后者包括一个保守的酪氨酸。