FITC标记的视网膜母细胞瘤结合蛋白6抗体
产品名称： FITC标记的视网膜母细胞瘤结合蛋白6抗体
英文名称： Anti-RBBP6/FITC
产品编号： HZ-6576R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-RBBP6/FITC Conjugated antibody
FITC标记的视网膜母细胞瘤结合蛋白6抗体
| 英文名称 | Anti-RBBP6/FITC |
| 中文名称 | FITC标记的视网膜母细胞瘤结合蛋白6抗体 |
| 别 名 | Retinoblastoma binding protein 6; RBBP6; MY038; P2P R; P2PR; p53 associated cellular protein of testis; PACT;Proliferationpotentialrelated protein; Protein P2P R; Protein P2PR; Protein RBQ 1; Protein RBQ1; RB binding Q protein 1; RBBP 6; RBQ 1; RBQ1; Retinoblastoma binding protein 6 isoform 3; Retinoblastoma binding Q protein 1; SNAMA; RBBP6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞凋亡 细胞周期蛋白 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 201kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RBBP6 (1265-1315aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. Retinoblastoma binding protein 6 binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. Function: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Subunit: Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6. Subcellular Location: ucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome. Tissue Specificity: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6. Similarity: Contains 1 CCHC-type zinc finger. Contains 1 DWNN domain. Contains 1 RING-type zinc finger. Database links: UniProtKB/Swiss-Prot: Q7Z6E9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
视网膜母细胞瘤肿瘤抑制蛋白（PRB）蛋白与许多其他蛋白结合。在各种人类癌症中，PRB抑制细胞增殖并被灭活。细胞周期依赖性磷酸化调节PRB的活性。视网膜母细胞瘤结合蛋白6结合磷酸化但未磷酸化的PRB。已发现多个交替编码的转录变体，编码不同的异构体。