FITC标记的氧化固醇结合蛋白4抗体-抗体-抗体-生物在线
FITC标记的氧化固醇结合蛋白4抗体

FITC标记的氧化固醇结合蛋白4抗体

商家询价

产品名称: FITC标记的氧化固醇结合蛋白4抗体

英文名称: Anti-ORP4/OSBP2/FITC

产品编号: HZ-6560R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

上海沪震实业有限公司
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  • 所在区域 : 上海
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  • 邮箱 : www.shzbio.net

 Rabbit Anti-ORP4/OSBP2/FITC Conjugated antibody

FITC标记的氧化固醇结合蛋白4抗体

 

英文名称 Anti-ORP4/OSBP2/FITC
中文名称 FITC标记的氧化固醇结合蛋白4抗体
别    名 ORP 4; ORP4; OSBLP4; OSBP-related protein 4; OSBP2; OSBPL1; OSBPL4; Oxysterol Binding Protein 2; Oxysterol Binding Protein-like 1; oxysterol binding protein-related protein 4; OSBP2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  信号转导  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ORP4/OSBP2 (231-280aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

Function:
Binds 7-ketocholesterol.

Subcellular Location:
Membrane; Peripheral membrane protein

Tissue Specificity:
Expressed mainly in retina, testis, and fetal liver.

Similarity:
Belongs to the OSBP family.
Contains 1 PH domain. 

Database links:

Entrez Gene: 23762 Human

Entrez Gene: 74309 Mouse

Entrez Gene: 305475 Rat

Omim: 606729 Human

SwissProt: Q969R2 Human

Unigene: 7740 Human

Unigene: 61022 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

磷脂酰肌醇结合蛋白(OSBP)家族由OsBP(OsBP1)和OsBP2(Orp4)组成,具有高度的整体相似性。OsBPs参与脂质代谢和信号转导,以及囊泡运输,并可转位到高尔基膜的周边时,它们结合到氧化甾醇。OsBP蛋白从溶酶体转运甾醇到细胞核,其中甾醇下调HMG合成酶基因、HMG-CoA还原酶和低密度脂蛋白受体(LDLR)基因。OsBP定位于胞浆,广泛表达,而OsBP2主要在睾丸、视网膜和胎肝中检测到。细胞外信号调节激酶(ERK)信号通路是通过OsBP通过其胆固醇结合特性来控制的。OsBP与25羟基胆固醇(25-HC)结合,对培养细胞中胆固醇合成基因转录的抑制。