FITC标记的星形胶质细胞PEA15抗体
产品名称: FITC标记的星形胶质细胞PEA15抗体
英文名称: Anti-PEA15/FITC
产品编号: HZ-3524R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
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Rabbit Anti-PEA15/FITC Conjugated antibody
FITC标记的星形胶质细胞PEA15抗体
英文名称 | Anti-PEA15/FITC |
中文名称 | FITC标记的星形胶质细胞PEA15抗体 |
别 名 | Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HUMMAT 1H; HUMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; PEA-15; PEA15 protein; PED; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes 15kD; Phosphoprotein enriched in diabetes; PEA15_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 免疫学 神经生物学 生长因子和激素 转录调节因子 激酶和磷酸酶 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 15kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human PEA15 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function. Function: Blocks Ras-mediated inhibition of integrin activationand modulates the ERK MAP kinase cascade. Inhibits RPS6KA3activities by retaining it in the cytoplasm (By similarity).Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity andapoptosis. Regulates glucose transport by controlling both thecontent of SLC2A1 glucose transporters on the plasma membrane andthe insulin-dependent trafficking of SLC2A4 from the cell interiorto the surface. Subunit: Binds RPS6KA3, MAPK3 and MAPK1. Transient interactionwith PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD. Subcellular Location: Cytoplasm. Note=Associated withmicrotubules. Tissue Specificity: Ubiquitously expressed. Most abundant intissues such as heart, brain, muscle and adipose tissue whichutilize glucose as an energy source. Lower expression inglucose-producing tissues. Higher levels of expression are found intissues from individuals with type 2 diabetes than in controls. Post-translational modifications: Phosphorylated by protein kinase C andcalcium-calmodulin-dependent protein kinase. These phosphorylationevents are modulated by neurotransmitters or hormones. Similarity: Contains 1 DED (death effector) domain. Database links: Entrez Gene: 8682 Human Entrez Gene: 18611 Mouse Omim: 603434 Human SwissProt: Q15121 Human SwissProt: Q62048 Mouse Unigene: 517216 Human Unigene: 544 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PED/PEA 15(富含糖尿病的星形胶质蛋白/富含星形胶质细胞的磷酸化蛋白15 kDa)是一种广泛表达的15 kDa蛋白,由包含典型死亡效应域(DE)序列和核输出信号的N末端区域和含有两个丝氨酸的C末端区域组成。磷酸化位点。PED/PEA 15参与了多种细胞过程的调节,包括细胞凋亡、整合素激活和胰岛素敏感细胞中的胰岛素敏感葡萄糖转运。丝氨酸104(蛋白激酶C位点)和丝氨酸116(CAMKII和AKT的底物)的磷酸化对于PED/PEA 15功能是必需的。