FITC标记的磷酸化p21激活激酶6抗体
产品名称： FITC标记的磷酸化p21激活激酶6抗体
英文名称： Anti-Phospho-PAK6(Ser560)/FITC
产品编号： HZ-3314R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-Phospho-PAK6(Ser560)/FITC Conjugated antibody
FITC标记的磷酸化p21激活激酶6抗体
| 英文名称 | Anti-Phospho-PAK6(Ser560)/FITC |
| 中文名称 | FITC标记的磷酸化p21激活激酶6抗体 |
| 别 名 | Phospho-PAK6(Ser560); PAK4 + PAK5 + PAK6 (phospho S474 + S602 + S560); CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human PAK6 around the phosphorylation site of Ser560 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B. Subcellular Location: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction. Tissue Specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. Post-translational modifications: Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CRIB domain. Database links: Entrez Gene: 56924 Human Omim: 608110 Human SwissProt: Q9NQU5 Human Unigene: 513645 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码与p21活化激酶（PAK）家族成员具有高度序列相似性的蛋白质。该家族的蛋白质是RAC/CDC42相关的STE20样SE/THR蛋白激酶，其特征在于高度保守的氨基末端CDC42/Rac相互作用结合（CRIB）结构域和羧基末端激酶结构域。PAK激酶参与多种细胞过程的调节，包括细胞骨架重排、凋亡和MAP激酶信号通路。该基因编码的蛋白质与雄激素受体（AR）相互作用，雄激素受体是一种类固醇激素依赖性转录因子，对男性的性别分化和发育具有重要意义。p21活化蛋白激酶6基因在睾丸和前列腺组织中高表达，编码蛋白与雄激素共同作用于细胞核内。