FITC标记的组蛋白相关Bmi1抗体-抗体-抗体-生物在线
FITC标记的组蛋白相关Bmi1抗体

FITC标记的组蛋白相关Bmi1抗体

商家询价

产品名称: FITC标记的组蛋白相关Bmi1抗体

英文名称: Anti-PCGF4/BMI1/FITC

产品编号: HZ-2999R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1ug/Test IF=1:200-800

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : www.shzbio.net

 Rabbit Anti-PCGF4/BMI1/FITC Conjugated antibody 

FITC标记的组蛋白相关Bmi1抗体

 

英文名称 Anti-PCGF4/BMI1/FITC
中文名称 FITC标记的组蛋白相关Bmi1抗体
别    名 B lymphoma Mo MLV insertion region; Bmi 1; BMI-1; MGC12685; Murine leukemia viral (bmi 1) oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18; BMI1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  干细胞  细胞凋亡  转录调节因子  激酶和磷酸酶  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, 
产品应用 Flow-Cyt=1ug/Test IF=1:200-800  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bmi1/PCGF4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.

Function:
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Subcellular Location:
Nucleus. Cytoplasm.

Post-translational modifications:
Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation.

Similarity:
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 100532731 Human

Entrez Gene: 648 Human

Entrez Gene: 12151 Mouse

Entrez Gene: 307151 Rat

Omim: 164831 Human

SwissProt: P35226 Human

SwissProt: P25916 Mouse

Unigene: 380403 Human

Unigene: 289584 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

Bmi1癌基因诱导端粒酶活性,使人乳腺上皮细胞永生化。Bmi1通过抑制p16依赖性衰老途径延长人成纤维细胞的复制寿命。

 

多梳组(PCG)基因通过表观染色质修饰参与细胞记忆的维持。最近的研究表明PCG基因在造血干细胞(HSC)自我更新中的作用,这是一种通过细胞分裂维持细胞记忆的过程。在PCG基因中,BMI1在干细胞遗传中起着核心作用,其强迫表达促进了HSC的自我更新。这些发现强调了表观遗传调控在造血干细胞自我更新中的重要性,并确定PCG基因作为治疗性HSC操作的潜在靶点。参与维持基因的转录抑制状态。改变染色质,使其在表达能力上发生遗传性改变。