FITC标记的金属蛋白酶抑制因子RECK抗体
产品名称： FITC标记的金属蛋白酶抑制因子RECK抗体
英文名称： Anti-RECK/FITC
产品编号： HZ-2901R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-RECK/FITC Conjugated antibody
| FITC标记的金属蛋白酶抑制因子RECK抗体 |
| 英文名称 | Anti-RECK/FITC |
| 中文名称 | FITC标记的金属蛋白酶抑制因子RECK抗体 |
| 别 名 | hRECK; Membrane anchored glycoprotein (metastasis and invasion); RECK protein; Reversion inducing cysteine rich protein with Kazal motifs; ST15; Suppression of tumorigenicity 15 (reversion inducing cysteine rich protein with kazal motifs); Suppressor of tumorigenicity 15; RECK_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 107kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RECK |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: RECK is a cysteine rich, extracellular protein with protease inhibitor like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase 9, a key enzyme involved in tumor invasion and metastasis. Function: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Subunit: Interacts with MMP-9. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. Post-translational modifications: N-glycosylated. Similarity: Contains 3 Kazal-like domains. Database links: Entrez Gene: 313488 Human Entrez Gene: 8434 Human Omim: 605227 Human SwissProt: O95980 Human SwissProt: Q5W0K6 Human Unigene: 388918 Human Unigene: 728961 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ReCK是一种富含半胱氨酸的胞外蛋白，具有蛋白酶抑制剂样结构域，其表达在许多肿瘤和由各种癌基因转化的细胞中被强烈抑制。在正常细胞中，这种膜锚定糖蛋白可作为基质金属蛋白酶9的负调控因子，基质金属蛋白酶是参与肿瘤侵袭和转移的关键酶。