FITC标记的粘蛋白4抗体
产品名称： FITC标记的粘蛋白4抗体
英文名称： Anti-MUC4/FITC
产品编号： HZ-1994R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-MUC4/FITC Conjugated antibody
FITC标记的粘蛋白4抗体
| 英文名称 | Anti-MUC4/FITC |
| 中文名称 | FITC标记的粘蛋白4抗体 |
| 别 名 | Mucin4; Mucin-4; Mucin 4; Muc4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; Mucin 4 cell surface associated; Mucin 4 tracheobronchial; Tracheobronchial mucin Fragment; MUC4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 微生物学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Mucin-4 beta chain |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq]. Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Subunit: A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. Mucin-4 beta chain: Cell membrane; Single-pass membrane protein. Mucin-4 alpha chain: Secreted. Isoform 3, 17: Cell membrane; Single-pass membrane protein. Isoform 11, 15: Secreted. Tissue Specificity: Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. Post-translational modifications: Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. mucrnin-4 alpha chain is highly O-glycosylated. mucin-4 beta chain is predominantly N-glycosylated. Similarity: Contains 1 AMOP domain. Contains 2 EGF-like domains. Contains 1 NIDO domain. Contains 1 VWFD domain. Database links: Entrez Gene: 4585 Human Entrez Gene: 140474 Mouse Omim: 158372 Human SwissProt: Q99102 Human SwissProt: Q8JZM8 Mouse Unigene: 369646 Human Unigene: 214599 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肿瘤生物标志Tumor biomarkers |
马库斯的主要成分是，在石灰亚、科隆和切尔维克斯中的凝胶表面的粘性的分泌，是高清糖化的蛋白质。这些糖蛋白在保护上皮细胞中发挥重要的作用，并在普遍肾上腺皮质和分化中产生了影响。这一基因在细胞表面上形成了综合膜糖蛋白，并可存在着异构体。在这一基因的变体中，这一基因的变数已被发现，但在许多情况下，所有这些变体都没有完成，但它们只是在肿瘤组织中才被发现。This Gene in the coding seq in the coding seQuence which has a变量number（> 100）of 48 nt坦克repeat .[ Provided by RefSEQ ] .