FITC标记的癌胚抗原单克隆抗体(包被)-抗体-抗体-生物在线
FITC标记的癌胚抗原单克隆抗体(包被)

FITC标记的癌胚抗原单克隆抗体(包被)

商家询价

产品名称: FITC标记的癌胚抗原单克隆抗体(包被)

英文名称: Anti-CEA(C3)/FITC

产品编号: HZ-1623M-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Mouse Anti-CEA(C3)/FITC Conjugated antibody

FITC标记的癌胚抗原单克隆抗体(包被)

 

英文名称 Anti-CEA(C3)/FITC
中文名称 FITC标记的癌胚抗原单克隆抗体(包被)
别    名 Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5; CD66e; CD66e; CD66e antigen; CEA; CEA; CEACAM5; CEAM5_HUMAN; DKFZp781M2392; Meconium antigen 100; OTTHUMP00000199032; OTTHUMP00000199033; OTTHUMP00000199034.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞类型标志物  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 C3
交叉反应 Human, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 150-200kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 Human Carcino Embryonic Antigen
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Function:
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Subunit:
Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Post-translational modifications:
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Similarity:
Belongs to the immunoglobulin superfamily. CEA family. 
Contains 7 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 1048 Human

Omim: 114890 Human

SwissProt: P06731 Human

Unigene: 709196 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 


CEA是一种胚胎性抗原,主要存在于胎儿消化道上皮组织,胰腺和肝癌中。CEA广泛存在各种上皮性肿瘤,尤其是胃肠道恶性肿瘤,CEA分布阳性类型与肿瘤的恶性度有关。CEA与EMA一样可作为上皮性恶性肿瘤的重要标记。
分子量为150-200 kDa。
该抗体与bsm-1624M(检测)(Mouse Anti-Human CEA Monoclonal)配对使用;主要用于ELISA试剂盒,胶体金试剂条制备生产都很好。大量订购可来电商议

CEA相关的细胞粘附分子(CEACAM)属于癌胚抗原(CEA)家族。它由七个CEACAM(CEACAM 1,CEACAM 3-CEACAM 8)和11个妊娠特异性糖蛋白(PSG 1-PSG 11)成员组成。CEA家族蛋白属于免疫球蛋白(Ig)超家族,由一个Ig可变区(IgV)和不同数量的Ig恒定区(IgC)组成。CEACAM分子通过跨膜结构域或糖基磷脂酰肌醇(GPI)锚被膜结合。CEACAM分子在上皮细胞或白细胞中差异表达。CEA/CEACAM 5在上皮源性肿瘤中的过度表达是其作为肿瘤标志物的广泛应用的基础。CEACAM家族成员的功能有很大差异:它们起着细胞粘附分子、肿瘤抑制因子、淋巴细胞调节因子和树突状细胞活化、奈瑟菌属和其他细菌的受体的作用。