FITC标记的磷酸化内收蛋白抗体
产品名称: FITC标记的磷酸化内收蛋白抗体
英文名称: Anti-phospho-beta Adducin (Ser713)/FITC
产品编号: HZ-12960R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-phospho-beta Adducin (Ser713)/FITC Conjugated antibody
FITC标记的磷酸化内收蛋白抗体
英文名称 | Anti-phospho-beta Adducin (Ser713)/FITC |
中文名称 | FITC标记的磷酸化内收蛋白抗体 |
别 名 | beta Adducin (phospho S713); p-beta Adducin (phospho S713); phospho-alpha Adducin(Ser726); phospho-gamma Adducin(Ser693); ADD1; ADD2; ADD3; ADDA; ADDB; ADDL; Adducin 1 (alpha); Adducin 1; Adducin 2 (beta); Adducin 2; Adducin 3 (gamma); Adducin 3; Adducin like; Alpha adducin; Beta adducin. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
产品类型 | 磷酸化抗体 |
研究领域 | 细胞生物 信号转导 细胞类型标志物 细胞骨架 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Zebrafish, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 80kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human beta Adducin around the phosphorylation site of Ser713 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Subunit: Heterodimer of an alpha and a beta subunit. Subcellular Location: Membrane-cytoskeleton-associated protein. Tissue Specificity: Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the aldolase class II family. Adducinbn subfamily. Database links: Entrez Gene: 119 Human Entrez Gene: 11519 Mouse Entrez Gene: 24171 Rat Omim: 102681 Human SwissProt: P35612 Human SwissProt: Q9QYB8 Mouse SwissProt: Q05764 Rat Unigene: 188528 Human Unigene: 11353 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
内收蛋白是由三个基因(α,β,γ)编码的细胞骨架蛋白家族。Adducin是一种由相关亚基组成的异源二聚蛋白,这些亚基由不同的基因产生,但具有相似的结构。α和β-内收蛋白包括蛋白酶抗性的N-末端区域和蛋白酶敏感的亲水性C-末端区域。α和γ-内收蛋白是普遍表达的。相反,β-内收蛋白在脑和造血组织中高表达。Adducin与Ca2+/钙调素具有高度亲和力,是蛋白激酶A和C的底物。选择性剪接导致多个变异体编码不同的异构体;然而,并非所有变异体都已完全描述。