FITC标记的B淋巴细胞衔接分子DAPP1抗体-抗体-抗体-生物在线
FITC标记的B淋巴细胞衔接分子DAPP1抗体

FITC标记的B淋巴细胞衔接分子DAPP1抗体

商家询价

产品名称: FITC标记的B淋巴细胞衔接分子DAPP1抗体

英文名称: Anti-DAPP1/FITC

产品编号: HZ-12982R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-DAPP1/FITC Conjugated antibody

FITC标记的B淋巴细胞衔接分子DAPP1抗体

 

英文名称 Anti-DAPP1/FITC
中文名称 FITC标记的B淋巴细胞衔接分子DAPP1抗体
别    名 B cell adapter molecule of 32 kDa; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; BAM32; DAPP1; DAPP1_HUMAN; DKFZp667E0716; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; Dual adaptor of phosphotyrosine and 3 phosphoinositides; hDAPP1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  神经生物学  淋巴细胞  b-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DAPP1/BAM32
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
B cell adapter molecule is also designated dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1) or B lymphocyte adapter protein. BAM32 is a B cell-associated adapter that is crucial for B cell antigen receptor signaling regulation. BAM32 interacts with Ptdlns and PLC g2 and, upon B cell activation, the protein is phosphorylated on tyrosine residues. It is a mainly cytoplasmic protein that can translocate to the cell membrane after cell stimulation. BAM32, which contains one PH domain and one SH2 domain, is primarily expressed in placenta and lung tissues, but can also be detected in heart, liver, pancreas and brain.

Function:
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Subunit:
Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2. 

Subcellular Location:
Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.

Tissue Specificity:
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

Post-translational modifications:
Phosphorylated on tyrosine residues.

Similarity:
Contains 1 PH domain.
Contains 1 SH2 domain.

Database links:
UniProtKB/Swiss-Prot: Q9UN19.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

B细胞适配分子也被指定为磷酸酪氨酸和3-磷酸酪氨酸和3-磷酸肌醇(DAPP1)或B淋巴细胞适配蛋白的双适配子。BAM32是B细胞相关的适配器,是B细胞抗原受体信号调节的关键。BAM32与PTDLNs和PLC G2相互作用,并且在B细胞活化时,蛋白质在酪氨酸残基上磷酸化。它是一种主要的细胞质蛋白,可在细胞刺激后转运到细胞膜上。BAM32包含一个PH结构域和一个SH2结构域,主要表达在胎盘和肺组织中,但也可以在心脏、肝脏、胰腺和大脑中检测到。