FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体-抗体-抗体-生物在线
FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体

FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体

商家询价

产品名称: FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体

英文名称: Anti-DNA polymerase delta p50/FITC

产品编号: HZ-13014R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-DNA polymerase delta p50/FITC Conjugated antibody

FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体

 

英文名称 Anti-DNA polymerase delta p50/FITC
中文名称 FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体
别    名 DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  细胞周期蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Macaque Monkey
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNA polymerase delta p50
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]. 

Function:
The function of the small subunit is not yet clear.

Subunit:
Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD10 (By similarity). Interacts with KCTD13/POLDIP1, POLDIP2 and POLDIP3. Interacts with WRNIP1. Interacts with POLD4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the DNA polymerase delta/II small subunit family.

Database links:
Entrez Gene: 281991 Cow
Entrez Gene: 5425 Human
Entrez Gene: 18972 Mouse
Entrez Gene: 289758 Rat
Omim: 600815 Human
SwissProt: P49004 Cow
SwissProt: P49005 Human
SwissProt: O35654 Mouse
SwissProt: Q6AXY4 Rat
Unigene: 306791 Human
Unigene: 35788 Mouse
Unigene: 22989 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码DNA聚合酶δ的50 kDa催化亚基。DNA聚合酶δ兼具聚合酶和3’-5’外切酶活性,在DNA复制和修复中起重要作用。编码蛋白是加工辅因子增殖细胞核抗原(PCNA)刺激DNA聚合酶δ活性所必需的。该基因的表达可能是卵巢癌的一个标志物。此外,还观察到编码多种同工型的剪接转录变异体,该基因的一个假基因位于5号染色体的长臂上。[ RefSeq,MAR 2012 ]提供。