FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体
产品名称: FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体
英文名称: Anti-DNA polymerase delta p50/FITC
产品编号: HZ-13014R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DNA polymerase delta p50/FITC Conjugated antibody
FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体
英文名称 | Anti-DNA polymerase delta p50/FITC |
中文名称 | FITC标记的DNA聚合酶δ2/DNA pol δ 2抗体 |
别 名 | DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 细胞周期蛋白 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Macaque Monkey |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 51kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human DNA polymerase delta p50 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]. Function: The function of the small subunit is not yet clear. Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD10 (By similarity). Interacts with KCTD13/POLDIP1, POLDIP2 and POLDIP3. Interacts with WRNIP1. Interacts with POLD4. Subcellular Location: Nucleus. Similarity: Belongs to the DNA polymerase delta/II small subunit family. Database links: Entrez Gene: 281991 Cow Entrez Gene: 5425 Human Entrez Gene: 18972 Mouse Entrez Gene: 289758 Rat Omim: 600815 Human SwissProt: P49004 Cow SwissProt: P49005 Human SwissProt: O35654 Mouse SwissProt: Q6AXY4 Rat Unigene: 306791 Human Unigene: 35788 Mouse Unigene: 22989 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码DNA聚合酶δ的50 kDa催化亚基。DNA聚合酶δ兼具聚合酶和3’-5’外切酶活性,在DNA复制和修复中起重要作用。编码蛋白是加工辅因子增殖细胞核抗原(PCNA)刺激DNA聚合酶δ活性所必需的。该基因的表达可能是卵巢癌的一个标志物。此外,还观察到编码多种同工型的剪接转录变异体,该基因的一个假基因位于5号染色体的长臂上。[ RefSeq,MAR 2012 ]提供。