FITC标记的内吞作用辅助蛋白EPN2抗体
产品名称： FITC标记的内吞作用辅助蛋白EPN2抗体
英文名称： Anti-Epsin 2/FITC
产品编号： HZ-13102R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Epsin 2/FITC Conjugated antibody
FITC标记的内吞作用辅助蛋白EPN2抗体
| 英文名称 | Anti-Epsin 2/FITC |
| 中文名称 | FITC标记的内吞作用辅助蛋白EPN2抗体 |
| 别 名 | EHB21; EPN 2; EPN-2; Epn2; EPN2_HUMAN; EPS 15 interacting protein 2; EPS-15-interacting protein 2; Eps15 binding protein; Epsin 2; Epsin-2; Epsin2; KIAA1065; OTTHUMP00000065808; OTTHUMP00000065809; OTTHUMP00000065810; OTTHUMP00000065811; OTTHUMP00000065889. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 生长因子和激素 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 69kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Epsin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates have been described, designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15. Epsin is a binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrin-mediated endocytosis. Epsin, along with its binding partner Eps15, is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2a, and 2b are splicing variants of epsin 2, which is associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region. Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis. Subunit: Binds EPS15 (By similarity). Binds AP-2 and clathrin. Subcellular Location: Cytoplasm. Cytoplasmic vesicle; clathrin-coated vesicle. In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex. Tissue Specificity: Highest expression is found in brain. Detected at lower levels in lung and liver. Post-translational modifications: Ubiquitinated. Similarity: Belongs to the epsin family. Contains 1 ENTH (epsin N-terminal homology) domain. Contains 2 UIM (ubiquitin-interacting motif) repeats. Database links: Entrez Gene: 22905 Human Entrez Gene: 13855 Mouse Entrez Gene: 60443 Rat Omim: 607263 Human SwissProt: O95208 Human SwissProt: Q8CHU3 Mouse SwissProt: Q9Z1Z3 Rat Unigene: 309467 Human Unigene: 139695 Mouse Unigene: 436466 Mouse Unigene: 44273 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
阐明受体酪氨酸激酶（RTKs）调节细胞生理学以响应刺激的机制对于理解生长调节是至关重要的。RTK信号通路中的错误可能导致细胞转化，最终导致癌症。已经描述了两种新的EGF受体底物，其命名为EGF受体途径底物8和15，或EPS8和EPS15。Epsin是EPS15的有约束力的合作伙伴。epsin和Eps15都具有普遍的组织分布，但都集中在突触前神经末梢，这些神经末梢专门用于Clathrin介导的突触小泡的内吞作用。干扰素功能块阻断网格蛋白介导的内吞作用。Epsin及其结合伴侣Eps15被提议参与在Clathrin涂层凹坑内陷期间协助Clathrin涂层重排。Epsin 2a和2b是epsin 2的剪接变异体，与Clathrin介导的内吞作用有关，并富集于高尔基体周围区域的脑内。