FITC标记的EYA4蛋白抗体-抗体-抗体-生物在线
FITC标记的EYA4蛋白抗体

FITC标记的EYA4蛋白抗体

商家询价

产品名称： FITC标记的EYA4蛋白抗体

英文名称： Anti-EYA4/FITC

产品编号： HZ-13126R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-EYA4/FITC Conjugated antibody

FITC标记的EYA4蛋白抗体

 

英文名称 Anti-EYA4/FITC
中文名称 FITC标记的EYA4蛋白抗体
别    名 CMD1J; Deafness, autosomal dominant 10; DFNA 10; DFNA10; dJ78N10.1 (eyes absent (Drosophila) homolog 4); dJ78N10.1 (eyes absent); EYA 4; eya4; EYA4_HUMAN; Eyes absent 4; Eyes absent homolog 4 (Drosophila); Eyes absent homolog 4; HGNC:3522; OTTHUMP00000040267.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  发育生物学  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EYA4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).

Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Highly expressed in heart and skeletal muscle.

DISEASE:
Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Similarity:
Belongs to the HAD-like hydrolase superfamily. EYA family.

Database links:

Entrez Gene: 2070 Human

Entrez Gene: 14051 Mouse

Omim: 603550 Human

SwissProt: O95677 Human

SwissProt: Q9Z191 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

染色体6q23的基因编码640个氨基酸蛋白，EYA4（眼睛缺失）（1）。EYA是无眼家族的四个成员之一（1）。羧基末端的271个氨基酸结构域在没有眼睛的家族成员中高度保守（1）。EYA4在颅颌面间质、真皮刀和肢体（1）中均有表达。其他EYA蛋白中的保守区与SIX、DACH和G蛋白相互作用，后者在早期胚胎发育中调节转录（1，2，3，4）。六将EYA1-3转运到细胞核，G蛋白可以阻止这种相互作用（3,4）。EAA4中的过早终止密码子突变导致人类语言后进行性常染色体显性听力丧失（2）。这表明EYA4也是Cordi（2）成熟器官的重要组成部分。EYA4可根据其表达模式和MAP定位（1）引起眼-趾综合征。