FITC标记的弹性蛋白结合蛋白Fcn2抗体
产品名称: FITC标记的弹性蛋白结合蛋白Fcn2抗体
英文名称: Anti-Ficolin 2/FITC
产品编号: HZ-13162R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Ficolin 2/FITC Conjugated antibody
FITC标记的弹性蛋白结合蛋白Fcn2抗体
英文名称 | Anti-Ficolin 2/FITC |
中文名称 | FITC标记的弹性蛋白结合蛋白Fcn2抗体 |
别 名 | 37 kDa elastin-binding protein; Collagen/fibrinogen domain containing protein 2; Collagen/fibrinogen domain-containing protein 2; EBP 37; EBP-37; EBP37; FCN 2; Fcn2; FCN2_HUMAN; FCNL; Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); Ficolin B; Ficolin beta; Ficolin-2; Ficolin-B; Ficolin-beta; Ficolin2; Hucolin; L ficolin; L-ficolin; OTTHUMP00000022518; P35; RP11 263F14.2; Serum lectin p35. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 心血管 细胞生物 免疫学 细胞凋亡 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 31kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Ficolin 2/Ficolin B |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
产品介绍 | background: Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beh鏴t's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups. Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Subunit: Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma. Similarity: Belongs to the ficolin lectin family. Contains 1 collagen-like domain. Contains 1 fibrinogen C-terminal domain. Database links: Entrez Gene: 2220 Human Omim: 601624 Human SwissProt: Q15485 Human Unigene: 54517 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Ficolin B在小鼠和大鼠中是一种蛋白质,也称为L-ficolin、ficolin-2、胶原/纤维蛋白原结构域蛋白2、血清凝集素p35、EBP-37或hucolin。Ficolin B是FICOLIN凝集素家族的313氨基酸成员。它是一种分泌的天然免疫模式识别分子,在肝脏和血浆中表达,形成二硫键连接的均聚物。这种广泛的N-末端二硫键形成可导致功能十二聚体多肽。Ficolin B结合晚期凋亡和坏死细胞表达的DNA配体,以增加附着和吞噬。个体间无花果素B浓度的变化与FCN2基因启动子和结构部分的多态性有关。在Beht's disease(BD)患者中,HLA-B51阳性和HLA-B51阴性亚群中,-557和-64启动子区FCN2基因单核苷酸多态性(SNP)等位基因频率存在显著差异。