FITC标记的IgG-Fc片断受体转运蛋白α抗体
产品名称： FITC标记的IgG-Fc片断受体转运蛋白α抗体
英文名称： Anti-FCGRT/FITC
产品编号： HZ-13151R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FCGRT/FITC Conjugated antibody
FITC标记的IgG-Fc片断受体转运蛋白α抗体
| 英文名称 | Anti-FCGRT/FITC |
| 中文名称 | FITC标记的IgG-Fc片断受体转运蛋白α抗体 |
| 别 名 | Alpha chain; Fc fragment of IgG, receptor transporter, alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 血管内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Sheep, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCGRT/FcRn |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins. Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Subunit: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Subcellular Location: Cell membrane. Similarity: Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Database links: Entrez Gene: 2217 Human Omim: 601437 Human SwissProt: P55899 Human Unigene: 111903 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
新生小鼠和大鼠肠上皮中存在的FcRN介导母奶中免疫球蛋白G(IgG)的选择性摄取，从而帮助新生动物获得被动免疫。FcRn(也称为FCGRT、Brambell受体、FcRn链、IgG Gc受体和新生儿Fc-受体)由重链和-2-微球蛋白组成。FCRN重链显示约35%氨基酸的身份MHC I类分子。FcRN定位于血管内皮细胞的内体并选择性地将IgG循环到细胞表面，从而保护IgG免受溶酶体分解代谢的影响。这种保护机制是确保IgG是所有血浆蛋白寿命最长的主要成分。