FITC标记的微小染色体维持缺陷蛋白7抗体
产品名称: FITC标记的微小染色体维持缺陷蛋白7抗体
英文名称: Anti-MCM7/FITC
产品编号: HZ-10319R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MCM7/FITC Conjugated antibody
FITC标记的微小染色体维持缺陷蛋白7抗体
英文名称 | Anti-MCM7/FITC |
中文名称 | FITC标记的微小染色体维持缺陷蛋白7抗体 |
别 名 | CDABP0042; CDC 47; CDC47; CDC47 homolog; DNA replication licensing factor MCM7; Homolog of S. cerevisiae Cdc47; MCM 2; MCM 7; MCM2; Mcm7; MCM7 minichromosome maintenance deficient 7; MCM7_HUMAN; Minichromosome Maintainence 7; Minichromosome maintenance complex component 7; Minichromosome maintenance deficient 7; Minichromosome maintenance protein 7; P1.1 MCM3; P1.1-MCM3; P1CDC47; P85MCM; PNAS 146; PNAS146. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 细胞凋亡 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 81kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human MCM7 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the MCM family. Contains 1 MCM domain. Database links: Entrez Gene: 4176 Human Entrez Gene: 17220 Mouse Entrez Gene: 288532 Rat Omim: 600592 Human SwissProt: P33993 Human SwissProt: Q61881 Mouse Unigene: 438720 Human Unigene: 378965 Mouse Unigene: 113 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码的蛋白是一种高度保守的微型染色体维持蛋白(MCM),真核基因组复制起始是必不可少的。由MCM蛋白形成的六聚体蛋白质复合物的预复制复合物的关键成分(pre_rc)可能参与复制叉的形成和在招聘其他DNA复制相关蛋白。MCM组成的复杂的蛋白质和蛋白质具有4和6的表达,DNA解旋酶活性,并可作为DNA解旋酶。Cyclin D1蛋白依赖性激酶CDK4,发现这种蛋白相关联,并可能参与调节蛋白质与抑癌蛋白Rb1 / Rb结合。另外,报道了编码不同亚型的剪接转录变体。[ RefSeq,JUL 2008 ]提供。