FITC标记的人肿瘤抑制蛋白抗体
产品名称： FITC标记的人肿瘤抑制蛋白抗体
英文名称： Anti-HELZ/FITC
产品编号： HZ-15450R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HELZ/FITC Conjugated antibody
FITC标记的人肿瘤抑制蛋白抗体
| 英文名称 | Anti-HELZ/FITC |
| 中文名称 | FITC标记的人肿瘤抑制蛋白抗体 |
| 别 名 | DKFZp586G1924; Down regulated in human cancers; DRHC; Helicase with zinc finger; HUMORF 5; HUMORF5; KIAA0054; MGC163454; Probable helicase with zinc finger domain; HELZ_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 219kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HELZ |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Helicases comprise a class of enzymes that function as motor proteins which move along nucleic acid phosphodiester bonds, effectively separating two annealed nucleic acid strands. RNA helicases alter the conformation of RNA, specifically by unwinding double-stranded RNA regions to yield single RNA strands, a process which changes the biological activity of the RNA molecule. HELZ (helicase with zinc finger), also known as DHRC or HUMORF5, is a 1,942 amino acid nuclear protein that contains one C3H1-type zinc finger and belongs to the RNA helicase superfamily. Expressed ubiquitously during embryonic development, HELZ is thought to function as an RNA helicase that modifies RNA structure and plays a role in the development of multiple organs and tissues within the developing embryo. Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Subunit: Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II. Subcellular Location: Nucleus (Probable). Tissue Specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines. Similarity: Belongs to the DNA2/NAM7 helicase family. Contains 1 C3H1-type zinc finger. Database links: UniProtKB/Swiss-Prot: P42694.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
螺旋体包括一类起运动蛋白作用的酶，它们沿着核酸磷酸二酯键运动，有效地分离两条退火的核酸链。RNA螺旋酶通过解开双链RNA区域产生单链RNA来改变RNA的构象，这个过程改变了RNA分子的生物活性。HELZ(带锌指的螺旋酶)又称DHRC或HUMORF5，是1942年氨基酸核蛋白，含有一个C3H1型锌指，属于RNA螺旋酶超家族。HELZ在胚胎发育过程中普遍表达，被认为是RNA螺旋酶的功能，它修饰RNA结构，并在发育中的胚胎内多个器官和组织的发育中发挥作用。