FITC标记的DENND5B蛋白抗体
产品名称： FITC标记的DENND5B蛋白抗体
英文名称： Anti-DENND5B/FITC
产品编号： HZ-14275R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-DENND5B/FITC Conjugated antibody
FITC标记的DENND5B蛋白抗体
| 英文名称 | Anti-DENND5B/FITC |
| 中文名称 | FITC标记的DENND5B蛋白抗体 |
| 别 名 | DENN domain containing protein 5B; DENN MADD domain containing 5B; Dennd5b; DEN5B_HUMAN； Rab6IP1 like protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | a |
| 抗体来源 | |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Chicken, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 145kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DENND5B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DENND5B is a 1,274 amino acid single-pass membrane protein containing a dDENN domain, a DENN domain, a PLAT domain, two RUN domains and an uDENN domain. Existing as four alternatively spliced isoforms, DENND5B is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. Subcellular Location: Membrane; Single-pass membrane protein. Similarity: Belongs to the RAB6IP1 family. Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 PLAT domain. Contains 2 RUN domains. Contains 1 uDENN domain. Database links: Entrez Gene: 160518 Human Entrez Gene: 320560 Mouse SwissProt: Q6ZUT9 Human SwissProt: A2RSQ0 Mouse Unigene: 118166 Human Unigene: 426874 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
dennd5b是一个1274个氨基酸的单跨膜蛋白含有ddenn域，一个因为域名，平台领域，两运行域和udenn域。四选择性剪接异构体的存在，dennd5b由基因位于人类12号染色体上编码，其编码基因，包括超过1100的人类基因组的约4.5%。12号染色体与一系列的骨骼畸形，包括相关的软骨形成不足，软骨病和Kniest发育不良。努南综合征，主要症状的心脏和面部发育缺陷，是由突变的PTPN11基因产品形式造成的，sh-ptp2。12号染色体是一个同源盒基因簇编码的关键转录因子的形态，和自然杀伤细胞复杂的基因簇编码的C型凝集素蛋白介导Ⅰ类相互作用的NK细胞应答。三体12p导致面部发育畸形、癫痫症和其他症状的严重程度取决于对嵌合体的程度不同，在完全的三体情况最严重。