FITC标记的DHX58蛋白抗体
产品名称： FITC标记的DHX58蛋白抗体
英文名称： Anti-DHX58/FITC
产品编号： HZ-14323R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DHX58/FITC Conjugated antibody
FITC标记的DHX58蛋白抗体
| 英文名称 | Anti-DHX58/FITC |
| 中文名称 | FITC标记的DHX58蛋白抗体 |
| 别 名 | D11LGP2; D11lgp2e; DEXH (Asp Glu X His) box polypeptide 58; DEXH box polypeptide 58; DHX 58; DHX58; DHX58_HUMAN; LGP 2; LGP2; Ortholog of mouse D11lgp2; Probable ATP dependent helicase LGP2; Probable ATP dependent RNA helicase DHX58; Probable ATP-dependent helicase LGP2; Probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2 homolog; RIG-I-like receptor LGP2; RLR; RNA helicase LGP2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细菌及病毒 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 77kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DHX58 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain. Function: Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower. Subcellular Location: Cytoplasm. Similarity: Belongs to the helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: Entrez Gene: 79132 Human Entrez Gene: 80861 Mouse Entrez Gene: 303538 Rat Omim: 608588 Human SwissProt: Q96C10 Human SwissProt: Q99J87 Mouse Unigene: 55918 Human Unigene: 271830 Mouse Unigene: 105654 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
DHX58是属于解旋酶家族的678氨基酸。LGP2通过结合在病毒复制过程中产生的dsRNA，作为宿主天然免疫防御的负调节因子。LGP2的阻遏结构域与RIG-I结合，这是一种参与丙型肝炎病毒（HCV）宿主防御的信号蛋白。通过防止RIG-I多聚，LGP2负调控RIG-I介导的信号传导。定位于细胞质中，LGP2包含一个解旋酶ATP结合结构域和一个解旋酶C-末端结构域。