FITC标记的丝氨酸消旋酶抗体
产品名称： FITC标记的丝氨酸消旋酶抗体
英文名称： Anti-Serine racemase/FITC
产品编号： HZ-10474R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Serine racemase/FITC Conjugated antibody
FITC标记的丝氨酸消旋酶抗体
| 英文名称 | Anti-Serine racemase/FITC |
| 中文名称 | FITC标记的丝氨酸消旋酶抗体 |
| 别 名 | D serine ammonia lyase; D serine dehydratase; D-serine ammonia-lyase; D-serine dehydratase; ILV1; ISO1; L serine ammonia lyase; L serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; Serine racemase; srr; SRR_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Serine racemase |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Known to be prominent in bacteria, D amino acids were generally thought to be absent in mammals. D-serine has since been found in high levels in the mammalian brain and in various mammalian fluids. D-serine activates N-methyl-D-aspartate (NMDA) receptors--molecules with important roles in learning, brain growth and brain cell death. Serine racemase is the enzyme catalyzing the formation of D-serine from L-serine. Serine racemase is a member of the family of pyridoxal-5’ phosphate-dependent enzymes and is localized to glial cells in rat brain. Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Subunit: Homodimer. Tissue Specificity: Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver. Post-translational modifications: S-nitrosylated, leading to decrease the enzyme activity. Similarity: Belongs to the serine/threonine dehydratase family. Database links: Entrez Gene: 63826 Human Omim: 606477 Human SwissProt: Q9GZT4 Human Unigene: 461954 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
已知在细菌中是显著的，D氨基酸通常被认为在哺乳动物中是不存在的。D-丝氨酸已被发现在哺乳动物大脑和各种哺乳动物流体中的高水平。D-丝氨酸激活N-甲基-D-天门冬氨酸(NMDA)受体--在学习、脑生长和脑细胞死亡中具有重要作用的分子。Serine racemase是催化L-丝氨酸形成D-丝氨酸的酶。丝氨酸消旋酶是吡哆醛-5'磷酸依赖性酶家族的成员，在大鼠脑中定位于神经胶质细胞。