FITC标记的DMRTC1蛋白抗体
产品名称： FITC标记的DMRTC1蛋白抗体
英文名称： Anti-DMRTC1/FITC
产品编号： HZ-14350R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DMRTC1/FITC Conjugated antibody
FITC标记的DMRTC1蛋白抗体
| 英文名称 | Anti-DMRTC1/FITC |
| 中文名称 | FITC标记的DMRTC1蛋白抗体 |
| 别 名 | DMRT like family C1; Dmrtc1; DMRTC_HUMAN; DMRTC1B; Doublesex and mab 3 related transcription factor C1; Doublesex mab 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DMRTC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DMRTC1 is a 182 amino acid nuclear protein that exists as three alternatively spliced isoforms and belongs to the DMRT family. Involved in sexual development, DMRTC1 is expressed in Sertoli cells in male testis but, unlike other DMRT family members, it does not contain a DM DNA-binding domain. The gene encoding DMRTC1 maps to the human X chromosome, which consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited, including Klinefelter's syndrome, Turner's syndrome, and Triple X syndrome. Function: The vertebrate DMRT gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila) and MAB-3 (Worm). Subcellular Location: Nuclear Tissue Specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many other tissues. Similarity: Belongs to the DMRT family. Database links: Entrez Gene: 63947 Human Entrez Gene: 728656 Human SwissProt: Q5HYR2 Human Unigene: 558685 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DMRTC1是一个182个氨基酸的核蛋白，以三个交替剪接的亚型存在，属于DMRT家族。DMRTC1参与性发育，在雄性睾丸支持细胞中表达，但与其他DMRT家族成员不同，它不包含DM DNA结合域。编码DMRTC1的基因定位于人类X染色体，由约1亿5300万个碱基对和近1000个基因组成。X和Y染色体的组合导致正常的男性发育，而X的两个拷贝导致正常的女性发育。存在许多与正在遗传的性染色体数目和组合不确定有关的情况，包括Klinefelter综合征、Turner综合征和三重X综合征。