Rabbit Anti-Niemann Pick C1 Like 1/FITC Conjugated antibody
|英文名称||Anti-Niemann Pick C1 Like 1/FITC|
|别 名||Niemann Pick C1 like protein 1; Niemann Pick disease type C1 gene like 1; Niemann-Pick C1-like protein 1; NPC1 LIKE 1; NPC1 Niemann Pick disease type C1 gene like 1; NPC1L1; NPC1L1 splice variant; NPCL1_HUMAN; Truncated Niemann Pick C1 like protein 1.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学 神经生物学 信号转导|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||146kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Niemann Pick C1 Like 1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
Belongs to the patched family. Contains 1 SSD (sterol-sensing) domain.
Entrez Gene: 29881 Human
Omim: 608010 Human
SwissProt: Q9UHC9 Human
Unigene: 567486 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因编码的蛋白为多价膜蛋白。它包含一个保守的N端Niemann-Pick C1(NPC1)结构域和一个推测的甾醇感测结构域(SSD)，该结构域包括YQRL基序，其作为质膜在其他蛋白质中跨高尔基体网络传输信号。该蛋白通过囊泡内吞作用将游离胆固醇吸收到细胞内，在肠胆固醇的吸收中起关键作用。它还具有运输α-生育酚（维生素E）的能力。药物依折麦布靶向该蛋白并抑制肠胆固醇和α-生育酚的吸收。此外，该蛋白可能在调节脂质代谢中起关键作用。该基因的多态性与血浆总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平和冠心病（CHD）风险相关。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。[ RefSeq，OCT 2009提供]