Anti-phospho-TYRO3 (Tyr681)抗体-抗体-抗体-生物在线
Anti-phospho-TYRO3 (Tyr681)抗体

Anti-phospho-TYRO3 (Tyr681)抗体

商家询价

产品名称: Anti-phospho-TYRO3 (Tyr681)抗体

英文名称: phospho-TYRO3 (Tyr681)

产品编号: YB--10681R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-phospho-TYRO3 (Tyr681)抗体

产品编号 YB-10681R
英文名称 phospho-TYRO3 (Tyr681)
中文名称 磷酸化受体酪氨酸激酶抗体
别    名 TYRO3(phospho Tyr681); TYRO3(phospho Y681); Brt; BYK; DTK; RSE; SKY; Tif; TYRO3; TYRO3_HUMAN; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY.  
规格价格 100ul/1580元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 神经生物学  信号转导  激酶和磷酸酶  细胞膜受体  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human TYRO3 around the phosphorylation site of Tyr681:KI(p-Y)SG 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Subunit:
Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Abundant in the brain and lower levels in other tissues.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. 
Contains 2 fibronectin type-III domains. 
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 
Contains 1 protein kinase domain.

SWISS:
Q06418

Gene ID:
7301

Database links:

Entrez Gene: 7301 Human

Entrez Gene: 22174 Mouse

Omim: 600341 Human

SwissProt: Q06418 Human

SwissProt: P55144 Mouse

Unigene: 381282 Human

Unigene: 2901 Mouse

Unigene: 424496 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 
产品图片
Sample: 
293T-UV(Human) Cell Lysate at 30 ug
Primary: Anti-phospho-TYRO3 (Tyr681)bs-10681R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 94 kD
Observed band size: 124 kD