FITC标记的自噬微管相关蛋白轻链3A/3B抗体
产品名称: FITC标记的自噬微管相关蛋白轻链3A/3B抗体
英文名称: Anti-LC3A/B/FITC
产品编号: HZ-20414R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-LC3A/B/FITC Conjugated antibody
FITC标记的自噬微管相关蛋白轻链3A/3B抗体
英文名称 | Anti-LC3A/B/FITC |
中文名称 | FITC标记的自噬微管相关蛋白轻链3A/3B抗体 |
别 名 | Autophagy related protein LC3 A; Autophagy related protein LC3 B; Autophagy related ubiquitin like modifier LC3 A; Autophagy related ubiquitin like modifier LC3 B; LC3; MAP1 light chain 3 like protein 1; MAP1 light chain 3 like protein 2; MAP1A/1B light chain 3 A; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1ALC3; MAP1BLC3; MAP1LC3A; MAP1LC3B; Microtubule associated protein 1 light chain 3 alpha; Microtubule associated protein 1 light chain 3 beta; Microtubule associated proteins 1A/1B light chain 3; Microtubule associated proteins 1A/1B light chain 3A; Microtubule associated proteins 1A/1B light chain 3B; MLP3A_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞骨架 细胞外基质 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, Guinea Pig, |
产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 14kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 2mg/1ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human LC3A/B |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Subcellular Location: Cytoplasmic. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3B binds to the autophagic membranes. Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Post-translational modifications: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Similarity: Belongs to the MAP1 LC3 family. Database links: Entrez Gene: 81631 Human Entrez Gene: 84557 Human Entrez Gene: 66734 Mouse Entrez Gene: 67443 Mouse Entrez Gene: 362245 Rat Entrez Gene: 64862 Rat Omim: 601242 Human Omim: 609604 Human SwissProt: Q9GZQ8 Human SwissProt: Q9H492 Human SwissProt: Q91VR7 Mouse SwissProt: Q9CQV6 Mouse SwissProt: Q62625 Rat SwissProt: Q6XVN8 Rat Unigene: 356061 Human Unigene: 196239 Mouse Unigene: 28357 Mouse Unigene: 41412 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞内稳态的主要贡献是细胞在细胞成分的形成和降解/去除之间取得平衡的能力。这种内部细胞转变的过程被称为自噬(自食),并且通过大约16个相互作用的蛋白质在人体内的通路来促进。LC3是一种泛素样修饰蛋白,是酵母Apg8的人类同源物,参与自噬体空泡的形成,称为自噬体。LC3表达为3个剪接变异体(LC3A、LC3B和LC3C),它们具有不同的组织分布,分别被加工成胞质膜结合形式和自噬体膜结合形式,称为LC3-I和LC3-II。自噬过程的破坏现在与一些癌症、神经退行性疾病和心脏病理的进展相关,其中LC3被广泛用作自噬的标志。