FITC标记的G蛋白家族RAB13蛋白抗体
产品名称： FITC标记的G蛋白家族RAB13蛋白抗体
英文名称： Anti-RAB13/FITC
产品编号： HZ-8736R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-RAB13/FITC Conjugated antibody
FITC标记的G蛋白家族RAB13蛋白抗体
| 英文名称 | Anti-RAB13/FITC |
| 中文名称 | FITC标记的G蛋白家族RAB13蛋白抗体 |
| 别 名 | Cell growth-inhibiting gene 4 protein; GIG4; Growth inhibiting gene 4 protein; RAB13; RAB13 member RAS oncogene family; RAB13_HUMAN; RAS associated protein RAB13; Ras related protein Rab13; Ras-related protein Rab-13. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAB13 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. Subunit: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1. Subcellular Location: Cell junction > tight junction. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Tissue Specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. Similarity: Belongs to the small GTPase superfamily. Rab family. Database links: Entrez Gene: 514541 Cow Entrez Gene: 5872 Human Entrez Gene: 68328 Mouse Entrez Gene: 81756 Rat Entrez Gene: 373105 Zebrafish Omim: 602672 Human SwissProt: Q58DS5 Cow SwissProt: P51153 Human SwissProt: Q5U0A6 Human SwissProt: Q9DD03 Mouse SwissProt: P35286 Rat SwissProt: Q7T3A4 Zebrafish Unigene: 151536 Human Unigene: 29355 Mouse Unigene: 9819 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
小GTPases Rab是细胞内膜转运的关键调节因子，从转运小泡的形成到与膜的融合。兔子在非活性的GDP结合形式和活性的GTP结合形式之间循环，后者能够招募到直接负责囊泡形成、运动、系留和融合的不同下游效应器集合到膜上。Rab参与细胞内循环，调节跨膜蛋白如紧密连接蛋白OCLN/occludin向质膜的转运。因此，它调节了紧密连接的组装和活性。此外，它还可以通过激活PKA信号通路和通过分别激活下游效应物PRKACA和MICALL2来重新组织肌动蛋白细胞骨架来调节紧密连接组装。通过其在紧密连接组装中的作用，可能在建立支持细胞屏障中发挥作用。通过调节内皮细胞趋化作用在血管生成中发挥作用。还涉及神经突起生长。也有人提出在高尔基膜后从TGN向内体再循环的转运中发挥作用。最后，它参与了胰岛素诱导的葡萄糖转运体GLUT4向质膜的转运，因此可能在葡萄糖稳态中发挥作用。