Anti-CACNB3抗体-抗体-抗体-生物在线
Anti-CACNB3抗体

Anti-CACNB3抗体

商家询价

产品名称: Anti-CACNB3抗体

英文名称: CACNB3

产品编号: YB--10432R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-CACNB3抗体

产品编号 YB-10432R
英文名称 CACNB3
中文名称 L型电压依赖型钙通道β3(L-type Ca++ CPβ3)抗体
别    名 CAB3; CACB3_HUMAN; CACNLB3; Calcium Channel Voltage Dependent Beta 3 Subunit; Calcium channel voltage-dependent subunit beta 3; FLJ58949; Voltage-dependent L-type calcium channel subunit beta-3.  
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CACNB3:101-200/484 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta3, also known as CACNB3 (Calcium channel voltage-dependent subunit beta 3), CACNLB3 or CAB3, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 3 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta3 exist due to alternative splicing events.

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG. 

Tissue Specificity:
Expressed mostly in brain, smooth muscle and ovary.

Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.

SWISS:
P54284

Gene ID:
784

Database links:

Entrez Gene: 784 Human

Entrez Gene: 12297 Mouse

Entrez Gene: 25297 Rat

Omim: 601958 Human

SwissProt: P54284 Human

SwissProt: P54285 Mouse

SwissProt: P54287 Rat

Unigene: 250712 Human

Unigene: 3544 Mouse

Unigene: 2808 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 
产品图片
Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IRS3) Polyclonal Antibody, Unconjugated (bs-0186R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining